{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:24:36Z","timestamp":1790202276849,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Cell &amp; Environment"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Plants maintain iron (Fe) homeostasis under varying environmental conditions by balancing processes such as Fe uptake, transport\u00a0and storage. In Arabidopsis, POPEYE (PYE), a basic helix\u2010loop\u2010helix transcription factor (TF), has been shown to play a crucial role in regulating this balance. In recent years, the mechanisms regulating Fe uptake have been well established but the upstream transcriptional regulators of Fe transport and storage are still poorly understood. In this study, we report that ELONGATED HYPOCOTYL5 (HY5), a basic leucine zipper (bZIP) TF which has recently been shown to play a crucial role in Fe homeostasis, interacts with PYE. Molecular, genetic\u00a0and biochemical approaches revealed that PYE and HY5 have overlapping as well as some distinct roles in the regulation of Fe deficiency response. We found that HY5 and PYE both act as a repressor of Fe transport genes such as\n                    <jats:italic>YSL3, FRD3, NPF5.9, YSL2, NAS4<\/jats:italic>\n                    \u00a0and\n                    <jats:italic>OPT3<\/jats:italic>\n                    . HY5 was found to directly bind on the promoter of these genes and regulate intercellular Fe transport. Further analysis revealed that HY5 and PYE directly interact at the same region on\n                    <jats:italic>PYE<\/jats:italic>\n                    and\n                    <jats:italic>NAS4<\/jats:italic>\n                    promoter. Overall, this study revealed that HY5 regulates Fe homeostasis by physically interacting with PYE as well as independently.\n                  <\/jats:p>","DOI":"10.1111\/pce.15090","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T09:00:35Z","timestamp":1723539635000},"page":"2647-2661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["ELONGATED HYPOCOTYL 5 (HY5) and POPEYE (PYE) regulate intercellular iron transport in plants"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3780-2539","authenticated-orcid":false,"given":"Samriti","family":"Mankotia","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Indian Institute of Science Education and Research (IISER) Mohali Punjab 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