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While previous research suggests that the TYLCV C2 protein plays a role in fostering mutualistic interactions between the virus and its insect vectors, the specific mechanisms remain unclear. In this study, we show that the C2 protein interferes with the salicylic acid (SA) defence pathway by disrupting TCP7\u2010like transcription factor\u2010mediated regulation of <jats:italic>TGA2<\/jats:italic> expression. Whitefly infestation increases the expression of TCP7\u2010like transcription factors (<jats:italic>TCP7\u2010L1<\/jats:italic> and <jats:italic>TCP7\u2010L2<\/jats:italic>), which subsequently trigger TGA2\u2010dependent activation of <jats:italic>BGL2<\/jats:italic> transcription, enhancing plant resistance to whiteflies. However, the TYLCV C2 protein interacts with these TCP7\u2010like factors, reducing their binding affinity to the <jats:italic>TGA2<\/jats:italic> promoter, which in turn suppresses <jats:italic>BGL2<\/jats:italic> expression in the SA signalling pathway. These findings provide new insights into how TYLCV C2 modulates TCP7\u2010like protein activity to impair SA\u2010mediated defences, contributing to the mutualistic relationship between TYLCV and whiteflies. This work deepens our understanding of the complex regulatory networks underlying these virus\u2010vector\u2010host interactions.<\/jats:p>","DOI":"10.1111\/pce.15411","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T10:42:52Z","timestamp":1738060972000},"page":"4039-4050","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Suppression of TGA2\u2010Mediated Salicylic Acid Defence by <i>Tomato Yellow Leaf Curl Virus<\/i> C2 via Disruption of TCP7\u2010Like Transcription Factor Activity in Tobacco"],"prefix":"10.1111","volume":"48","author":[{"given":"Ping","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory for Quality and Safety of Agro\u2010Products, Key Laboratory of Biotechnology in Plant Protection of MARA, Zhejiang Key Laboratory of Green Plant Protection, Institute of Plant Virology, Ningbo University Ningbo China"},{"name":"Ministry of Agriculture 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