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Specifically, we investigated its functions in <jats:italic>Arabidopsis thaliana<\/jats:italic> leaf development and disease resistance. Our physiological analysis revealed that AtALMT9 negatively regulates leaf development and the immune response to pathogenic microorganisms. Moreover, RNA\u2010seq and qRT\u2010PCR analyses indicated leaf aging\u2010 and immunity\u2010related genes were significantly differentially expressed in <jats:italic>almt9<\/jats:italic> mutant plants. Furthermore, the impaired leaf development and accelerated disease resistance of the <jats:italic>almt9<\/jats:italic> mutant were due to the decreased contents of chlorophyll and malic acid as well as the increased levels of salicylic acid and jasmonic acid. This study provides new findings in the molecular mechanism underlying the involvements of AtALMT9 in leaf development and disease resistance, potentially providing a theoretical basis for enhancing agricultural productivity.<\/jats:p>","DOI":"10.1111\/pce.15630","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T07:23:44Z","timestamp":1747725824000},"page":"6509-6523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["AtALMT9 Modulates Leaf Development and Disease Resistance in <i>Arabidopsis thaliana<\/i>"],"prefix":"10.1111","volume":"48","author":[{"given":"Hanshu","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Nutrient Use and Management, College of Resources and Environmental Sciences, National Academy of Agriculture Green Development China Agricultural University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Song","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Nutrient Use and Management, College of Resources and Environmental Sciences, National Academy of Agriculture Green Development China Agricultural University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaonan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Nutrient Use and Management, College of Resources and Environmental Sciences, National Academy of Agriculture Green Development China Agricultural University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Mu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Nutrient Use and Management, College of Resources and Environmental Sciences, National Academy of Agriculture Green Development China Agricultural University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xujian","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Nutrient Use and Management, College of Resources and Environmental Sciences, National Academy of Agriculture Green Development China Agricultural University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7034-4445","authenticated-orcid":false,"given":"Jingbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Nutrient Use and Management, College of Resources and Environmental Sciences, National Academy of Agriculture Green Development China Agricultural University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2815"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0960-7412.2009.03782.x"},{"issue":"2","key":"e_1_2_7_4_1","first-page":"1167","article-title":"Vacuolar Chloride Fluxes Impact Ion Content and Distribution During Early Salinity Stress","volume":"172","author":"Baetz U.","year":"2016","journal-title":"Plant Physiology"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12101496"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3040.2011.02474.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11103-005-4090-1"},{"issue":"17","key":"e_1_2_7_8_1","first-page":"3167","article-title":"Recent Updates on ALMT Transporters\u2019 Physiology, Regulation, and Molecular Evolution in Plants","volume":"12","author":"Dabravolski S. 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