{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T11:54:13Z","timestamp":1782129253519,"version":"3.54.5"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Cell &amp; Environment"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cadmium (Cd) is a significant environmental pollutant with widespread detrimental effects on living organisms, making it a frequent subject of laboratory studies. However, different types of Cd salts are used to spike media, often without considering the possibility that accompanying anions may influence the effects of metal cations. Using two commonly used Cd salts, CdSO\n                    <jats:sub>4<\/jats:sub>\n                    and CdCl\n                    <jats:sub>2<\/jats:sub>\n                    , we observed distinct toxicity effects on\n                    <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                    development. On a physiological level, 7\u2010day\u2010old seedlings exposed to 50\u2009\u00b5M CdSO\n                    <jats:sub>4<\/jats:sub>\n                    had shorter roots than those treated with CdCl\n                    <jats:sub>2<\/jats:sub>\n                    . Proteomic analysis revealed strong downregulation of proteins involved in microtubule organization and primary cell wall synthesis in the root of plants exposed to CdSO\n                    <jats:sub>4<\/jats:sub>\n                    . Additionally, these plants exhibited higher Cd uptake from the medium and greater Cd accumulation in the shoot, indicating that the SO\n                    <jats:sub>4<\/jats:sub>\n                    <jats:sup>2\u2212<\/jats:sup>\n                    , as an accompanying anion, exacerbates Cd toxicity. These findings highlight the critical but often overlooked role of accompanying anions in modulating the toxic effects of heavy metals on plants.\n                  <\/jats:p>","DOI":"10.1111\/pce.70365","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T05:57:01Z","timestamp":1767765421000},"page":"2069-2079","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proteomic Analysis Reveals Accompanying Anion\u2010Dependent Changes of Cadmium Toxicity During\n                    <i>Arabidopsis thaliana<\/i>\n                    Development"],"prefix":"10.1111","volume":"49","author":[{"given":"Martin","family":"Ly\u010dka","sequence":"first","affiliation":[{"name":"Mendel Centre for Plant Genomics and Proteomics, Central European Institute of Technology (CEITEC) Masaryk University Brno Czech Republic"},{"name":"National Centre for Biomolecular Research, Faculty of Science Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"V\u00e1vra","sequence":"additional","affiliation":[{"name":"National Centre for Biomolecular Research, Faculty of Science Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Pot\u011b\u0161il","sequence":"additional","affiliation":[{"name":"Proteomics Core Facility, CEITEC Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ond\u0159ej","family":"Helia","sequence":"additional","affiliation":[{"name":"Mendel Centre for Plant Genomics and Proteomics, Central European Institute of Technology (CEITEC) Masaryk University Brno Czech Republic"},{"name":"National Centre for Biomolecular Research, Faculty of Science Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luk\u00e1\u0161","family":"Fojt","sequence":"additional","affiliation":[{"name":"Institute of Biophysics of the Czech Academy of Sciences Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u0159\u00ed","family":"Fajkus","sequence":"additional","affiliation":[{"name":"Mendel Centre for Plant Genomics and Proteomics, Central European Institute of Technology (CEITEC) Masaryk University Brno Czech Republic"},{"name":"National Centre for Biomolecular Research, Faculty of Science Masaryk University Brno Czech Republic"},{"name":"Institute of Biophysics of the Czech Academy of Sciences Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2419-2487","authenticated-orcid":false,"given":"Miloslava","family":"Fojtov\u00e1","sequence":"additional","affiliation":[{"name":"Mendel Centre for Plant Genomics and Proteomics, Central European Institute of Technology (CEITEC) Masaryk University Brno Czech Republic"},{"name":"National Centre for Biomolecular Research, Faculty of Science Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envexpbot.2018.05.008"},{"key":"e_1_2_7_3_1","first-page":"395","volume-title":"Cadmium Toxicity in Plants. In Metal Ions in Life Sciences","author":"Andresen E.","year":"2013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/plcell\/koad023"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.111.093575"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1511"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr101065j"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.13071"},{"key":"e_1_2_7_9_1","first-page":"754","volume-title":"An Aligned Rank Transform Procedure for Multifactor Contrast Tests. In The 34th Annual ACM Symposium on User Interface Software and Technology","author":"Elkin L. A.","year":"2021"},{"key":"e_1_2_7_10_1","unstructured":"Gianetto Q.2021. \u201cimp4p: Imputation for Proteomics.\u201d R package version 1.2 0.https:\/\/CRAN.R-project.org\/package=imp4p."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.113761"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.172046"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2020.111887"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12870-018-1255-z"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.200816"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.010359"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.111.092254"},{"key":"e_1_2_7_18_1","unstructured":"Kohl M.2022. MKmisc: Miscellaneous Functions from M. Kohl. R package version 1.9.https:\/\/CRAN.R-project.org\/package=MKmisc."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11104-013-1617-0"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11503"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apgeochem.2019.104388"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v025.i01"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.114.126193"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.109.142414"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1118560109"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.130527"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1004333529886"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1004381413048"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1071\/S96032"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.111.095059"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erq282"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00358-0"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/mp\/sst111"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11104-006-9164-6"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1126551"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/pce.12280"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706592104"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2020.01.026"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants10051007"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1002-0160(20)60002-9"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz369"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.261.5124.1032"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0098-8472(98)00058-6"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.136665"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.04.208"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.2134\/jeq1998.00472425002700020025x"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00011642"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.2136\/sssaj1996.03615995006000050022x"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/07352689.2020.1792179"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021800"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1131"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.17221\/909\/2013-PSE"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139091"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00294-014-0442-1"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eehl.2022.10.004"},{"key":"e_1_2_7_57_1","doi-asserted-by":"crossref","unstructured":"Wobbrock J. O. L.Findlater D.Gergle andJ. J.Higgins.2011.The Aligned Rank Transform for Nonparametric Factorial Analyses Using Only ANOVA Procedures. InProceedings of the SIGCHI Conference on Human Factors in Computing Systems. pp.143\u2013146.ACM.","DOI":"10.1145\/1978942.1978963"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/pce.13453"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plantsci.2007.05.004"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erv391"}],"container-title":["Plant, Cell &amp; Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pce.70365","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pce.70365","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pce.70365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T11:44:48Z","timestamp":1782128688000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pce.70365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,6]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/pce.70365"],"URL":"https:\/\/doi.org\/10.1111\/pce.70365","archive":["Portico"],"relation":{},"ISSN":["0140-7791","1365-3040"],"issn-type":[{"value":"0140-7791","type":"print"},{"value":"1365-3040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,6]]},"assertion":[{"value":"2025-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}