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The\n                    <jats:italic>dapat<\/jats:italic>\n                    mutant, which is deficient in\n                    <jats:italic>L,L<\/jats:italic>\n                    \u2010diaminopimelate aminotransferase (DAPAT), exhibits severe growth inhibition associated with broad metabolic imbalance. This metabolic reprogramming is characterised by simultaneous depletion of carbohydrates (sugars and starch), and organic acids, accompanied by elevated amino acid pools, reflecting a profound disruption of carbon\u2013nitrogen balance. These metabolic constraints coincide with altered expression of gibberellin (GA) biosynthetic genes (\n                    <jats:italic>CPS<\/jats:italic>\n                    ,\n                    <jats:italic>KS<\/jats:italic>\n                    ,\n                    <jats:italic>GA3ox1<\/jats:italic>\n                    ), suggesting a potential link between lysine metabolism, energy status, and GA\u2010mediated growth regulation. We therefore hypothesised that aberrant developmental defects in\n                    <jats:italic>dapat<\/jats:italic>\n                    arise from impaired GA metabolism. To test this hypothesis, we treated mutant plants with exogenous GA\u2083. Multivariate metabolomic analysis revealed a striking disconnect: GA restored the normal morphological phenotype of\n                    <jats:italic>dapat<\/jats:italic>\n                    but failed to correct the underlying metabolic dysfunction. GA\u2010treated\n                    <jats:italic>dapat<\/jats:italic>\n                    plants maintain amino acid remobilisation despite growth restoration, as indicated by pronounced\n                    <jats:italic>DIN6<\/jats:italic>\n                    induction, a marker of catabolic stress following energy starvation. These findings establish that lysine biosynthesis represents a critical metabolic constraint on plant development, and that growth hormone signalling can decouple morphological rescue from metabolic homoeostasis. This work exposes a fundamental mechanistic uncoupling between hormone\u2010induced growth and energy balance in lysine\u2010deficient plants, highlighting the critical role of lysine metabolism in integrating developmental and energetic cues.\n                  <\/jats:p>","DOI":"10.1111\/pce.70525","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T11:36:34Z","timestamp":1776339394000},"page":"5343-5357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lysine Biosynthesis Defines a Metabolic Checkpoint for Gibberellin\u2010Mediated Growth in\n                    <i>Arabidopsis thaliana<\/i>"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9904-3585","authenticated-orcid":false,"given":"D\u00e9bora Gon\u00e7alves","family":"Gouveia","sequence":"first","affiliation":[{"name":"National Institute of Science and Technology on Plant Physiology Under Stress Conditions, Departamento de Biologia Vegetal Universidade Federal de Vi\u00e7osa Vi\u00e7osa Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7023-0659","authenticated-orcid":false,"given":"Wesley E Bhering","family":"Barrios","sequence":"additional","affiliation":[{"name":"National Institute of Science and Technology on Plant Physiology Under Stress Conditions, Departamento de Biologia Vegetal Universidade Federal de Vi\u00e7osa Vi\u00e7osa Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auxiliadora Oliveira","family":"Martins","sequence":"additional","affiliation":[{"name":"National Institute of Science and Technology on Plant Physiology Under Stress Conditions, Departamento de Biologia Vegetal Universidade Federal de Vi\u00e7osa Vi\u00e7osa Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1136-6564","authenticated-orcid":false,"given":"Jo\u00e3o Henrique","family":"Cavalcanti","sequence":"additional","affiliation":[{"name":"Instituto de Educa\u00e7\u00e3o, Agricultura e Ambiente Universidade Federal do Amazonas Humait\u00e1 Amazonas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"La\u00edse","family":"Rosado\u2010Souza","sequence":"additional","affiliation":[{"name":"Max\u2010Planck\u2010Institut f\u00fcr Molekulare Pflanzenphysiologie Potsdam\u2010Golm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0775-9875","authenticated-orcid":false,"given":"Joa\u0303o Antonio","family":"Siqueira","sequence":"additional","affiliation":[{"name":"National Institute of Science and Technology on Plant Physiology Under Stress Conditions, Departamento de Biologia Vegetal Universidade Federal de Vi\u00e7osa Vi\u00e7osa Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1842-420X","authenticated-orcid":false,"given":"Danilo","family":"de Menezes Daloso","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Biologia Molecular Universidade Federal do Cear\u00e1 Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisdair R.","family":"Fernie","sequence":"additional","affiliation":[{"name":"Max\u2010Planck\u2010Institut f\u00fcr Molekulare Pflanzenphysiologie Potsdam\u2010Golm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9581-9355","authenticated-orcid":false,"given":"Adriano","family":"Nunes\u2010Nesi","sequence":"additional","affiliation":[{"name":"National Institute of Science and Technology on Plant Physiology Under Stress Conditions, Departamento de Biologia Vegetal Universidade Federal de Vi\u00e7osa Vi\u00e7osa Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas P. 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