{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:21:14Z","timestamp":1785860474586,"version":"3.56.0"},"reference-count":57,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Cell &amp;amp; Environment"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cyanobacteria operate a photosynthetic CO\n                    <jats:sub>2<\/jats:sub>\n                    concentrating mechanism (CCM) to cope with the low inorganic carbon (Ci) concentration in natural aquatic environment. Unlike in higher plants, transcription factors (TF) identified to improve photosynthesis and growth or to participate in the regulation of CCM are relatively limited. In this work, we constructed a gene co\u2010expression network (GCN) with transcriptome data from multi\u2010timepoint treatments under varied CO\n                    <jats:sub>2<\/jats:sub>\n                    concentrations in\n                    <jats:italic>Synechocystis<\/jats:italic>\n                    sp. PCC 6803, to systematically identify CO\n                    <jats:sub>2<\/jats:sub>\n                    responsive regulators. New regulatory factors of CCM components (including Ci transporters, CO\n                    <jats:sub>2<\/jats:sub>\n                    uptake systems, and NDH complex) were identified, and subsequent functional validation revealed that overexpression of\n                    <jats:italic>slr6040<\/jats:italic>\n                    or\n                    <jats:italic>sll5097<\/jats:italic>\n                    could facilitate the photosynthetic growth of\n                    <jats:italic>Synechocystis<\/jats:italic>\n                    6803, especially under low Ci conditions. Gene expression analysis in overexpressing strains showed that elevated Slr6040 or Sll5097 could up\u2010regulate the expression of CCM related genes. Yeast one\u2010hybrid and EMSA assays indicated direct regulation of target gene by Slr6040 in a metabolite coregulator dependent manner. Our full\u2010scale CO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010responsive regulatory network provided resources for further mining putative regulatory modules of cyanobacteria CCM in future studies, as well as for exploring the potential of engineering cyanobacteria with more efficient assimilation of CO\n                    <jats:sub>2<\/jats:sub>\n                    and improved productivities.\n                  <\/jats:p>","DOI":"10.1111\/pce.70620","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:29:38Z","timestamp":1780396178000},"page":"6601-6620","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Low CO\n                    <sub>2<\/sub>\n                    Responsive Gene Co\u2010Expression Network Identifies Regulators Facilitating Photosynthetic Growth of\n                    <i>Synechocystis<\/i>\n                    sp. Strain PCC 6803"],"prefix":"10.1111","volume":"49","author":[{"given":"Jiachun","family":"Wu","sequence":"first","affiliation":[{"name":"Key Laboratory of Plant Carbon Capture, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences Shanghai China"},{"name":"University of Chinese Academy of Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plant Carbon Capture, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Lv","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plant Carbon Capture, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences Shanghai China"},{"name":"University of Chinese Academy of Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitong","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plant Carbon Capture, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences Shanghai China"},{"name":"School of Life Sciences and Technology Tongji University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plant Carbon Capture, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences Shanghai China"},{"name":"University of Chinese Academy of Sciences Beijing 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