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While certain transcription factors have been implicated in stress responses, the core transcriptional networks governing immunity in tea plants remain largely elusive. In this study, we identify\n                    <jats:italic>CsWRKY33<\/jats:italic>\n                    as a central regulator that orchestrates immune responses and metabolic reprogramming during\n                    <jats:italic>C. camelliae<\/jats:italic>\n                    infection in tea plants. Transcriptome analysis revealed that\n                    <jats:italic>CsWRKY33<\/jats:italic>\n                    is significantly induced upon fungal challenge and functions downstream of both pattern\u2010triggered immunity (PTI) and effector\u2010triggered immunity (ETI). Mechanistically, protein\u2010promoter affinity experiments demonstrated that CsWRKY33 directly binds to W\u2010box motifs in the promoters of key immune genes, including\n                    <jats:italic>CsSERK2<\/jats:italic>\n                    ,\n                    <jats:italic>CsMPK3<\/jats:italic>\n                    ,\n                    <jats:italic>CsCDPK32<\/jats:italic>\n                    ,\n                    <jats:italic>CsPR1B<\/jats:italic>\n                    ,\n                    <jats:italic>CsWIN2<\/jats:italic>\n                    and\n                    <jats:italic>CsRPM1<\/jats:italic>\n                    . Dual\u2010luciferase assays and functional validations further confirmed that CsWRKY33 activates its expression, forming a positive feedback loop that amplifies immune signalling. Concurrently, CsWRKY33 modulates primary metabolism by repressing photosynthetic genes such as\n                    <jats:italic>CsRCA<\/jats:italic>\n                    and enhances secondary metabolism by directly activating phenylpropanoid pathway genes such as\n                    <jats:italic>CsPAL<\/jats:italic>\n                    and\n                    <jats:italic>CsCAD1<\/jats:italic>\n                    . These coordinated transcriptional programmes reallocate energy and resources toward defence, thereby enhancing resistance. We propose a working model in which CsWRKY33 serves as a transcriptional hub linking immune activation with metabolic adjustment to facilitate efficient defence. This study provides new insights into WRKY\u2010mediated immunity in perennial woody plants and highlights\n                    <jats:italic>CsWRKY33<\/jats:italic>\n                    as a promising target for molecular breeding of anthracnose\u2010resistant tea cultivars.\n                  <\/jats:p>","DOI":"10.1111\/pce.70684","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T09:59:32Z","timestamp":1781776772000},"page":"7103-7119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CsWRKY33 Integrates Immune Signalling and Metabolic Reprogramming to Enhance Tea Plant Resistance Against\n                    <i>Colletotrichum camelliae<\/i>"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3439-1087","authenticated-orcid":false,"given":"Tongtong","family":"Li","sequence":"first","affiliation":[{"name":"School of Life Sciences Anhui Agricultural University Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahai","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Life Sciences Anhui Agricultural University Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Fang","sequence":"additional","affiliation":[{"name":"School of Life Sciences Anhui Agricultural University Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Sciences Anhui Agricultural University Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Jiang","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Tea Plant Germplasm Innovation and Resource Utilization Anhui Agricultural University Hefei Anhui 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