{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:28:59Z","timestamp":1786969739019,"version":"build-2736575974"},"reference-count":100,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2023YFF1001200"],"award-info":[{"award-number":["2023YFF1001200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["lzujbky\u20102025\u2010jdzx05"],"award-info":[{"award-number":["lzujbky\u20102025\u2010jdzx05"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Cell &amp; Environment"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Reactive oxygen, nitrogen, and sulfur species (RONSs) are essential signaling molecules in plants, with their production highly compartmentalized within the cell. In this review, we advance the concept of the \u201cnuclear redox code,\u201d a framework in which the plant cell nucleus functions as a signaling hub that actively curates its own redox environment and translates oxidative signals into cellular decisions. We summarize current knowledge on the maintenance of nuclear redox homeostasis, the oxidative modification of nuclear proteins and chromatin, and how these modifications influence gene expression, cell cycle progression, and cell fate determination. We propose that the nucleus integrates these molecular events through a hierarchical architecture, coupling transient oxidative post\u2010translational modifications with stable chromatin marks to coordinate growth, development, and stress adaptation. We also highlight key unresolved questions and discuss how a systems\u2010level understanding of the nuclear redox code may guide the development of stress\u2010resilient crops.<\/jats:p>","DOI":"10.1111\/pce.70818","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:12:39Z","timestamp":1786968759000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Nuclear Redox Code: Orchestrating Growth, Development, and Stress Resilience"],"prefix":"10.1111","author":[{"given":"Feifei","family":"Huang","sequence":"first","affiliation":[{"name":"Gansu Province Key Laboratory of Gene Editing for Breeding, Ministry of Education on Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences Lanzhou University Lanzhou China"},{"name":"International Research Center for Environmental Membrane Biology &amp; Department of Horticulture Foshan University Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Lv","sequence":"additional","affiliation":[{"name":"Gansu Province Key Laboratory of Gene Editing for Breeding, Ministry of Education on Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences Lanzhou University Lanzhou China"},{"name":"International Research Center for Environmental Membrane Biology &amp; Department of Horticulture Foshan University Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5817-3831","authenticated-orcid":false,"given":"Feihua","family":"Wu","sequence":"additional","affiliation":[{"name":"Gansu Province Key Laboratory of Gene Editing for Breeding, Ministry of Education on Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences Lanzhou University Lanzhou China"},{"name":"International Research Center for Environmental Membrane Biology &amp; Department of Horticulture Foshan University Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/pce.14262","article-title":"Nuclear and Peroxisomal Targeting of Catalase","volume":"45","author":"Al\u2010Hajaya Y.","year":"2022","journal-title":"Plant, Cell & Environment"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1038\/s41467-023-37341-y","article-title":"Excessive Reactive Oxygen Species Induce Transcription\u2010Dependent Replication Stress","volume":"14","author":"Andrs M.","year":"2023","journal-title":"Nature Communications"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1093\/plphys\/kiac603","article-title":"Organelle\u2010Targeted Biosensors Reveal Distinct Oxidative Events During Pattern\u2010Triggered Immune Responses","volume":"191","author":"Arnaud D.","year":"2023","journal-title":"Plant Physiology"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1104\/pp.106.090902","article-title":"Diverse Subcellular Locations of Cryptogein\u2010Induced Reactive Oxygen Species Production in Tobacco Bright Yellow\u20102 Cells","volume":"143","author":"Ashtamker C.","year":"2007","journal-title":"Plant Physiology"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1093\/jxb\/erae165","article-title":"Redox Regulation of Epigenetic and Epitranscriptomic Gene Regulatory Pathways in Plants","volume":"75","author":"Auverlot J.","year":"2024","journal-title":"Journal of Experimental Botany"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2024.102435","article-title":"A New Era of Cysteine Proteomics \u2010 Technological Advances in Thiol Biology","volume":"79","author":"Burger N.","year":"2024","journal-title":"Current Opinion in Chemical Biology"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1126\/science.adj7249","article-title":"H2O2 Sulfenylates CHE, Linking Local Infection to the Establishment of Systemic Acquired Resistance","volume":"385","author":"Cao L.","year":"2024","journal-title":"Science"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.devcel.2015.05.011","article-title":"Chloroplast Stromules Function During Innate Immunity","volume":"34","author":"Caplan J. 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