{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:17:30Z","timestamp":1788265050460,"version":"build-2803163510"},"reference-count":121,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Cell &amp; Environment"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Selective autophagy has emerged as a critical component of plant immunity, yet its role as a dedicated antimicrobial mechanism, xenophagy, remains conceptually underdeveloped. In plants, xenophagy extends beyond bulk degradation to function as a highly regulated, cargo\u2010specific pathway that targets invading pathogens and their effector molecules for autophagic clearance. Recent evidence demonstrates that selective autophagy receptors, particularly NBR1, integrate ubiquitin\u2010mediated recognition with ATG8\u2010dependent sequestration, enabling the elimination of bacterial, fungal, and viral components. However, this process is not merely degradative but operates at the intersection of immune signaling, proteostasis, and cellular decision\u2010making. Here, we synthesize current advances in plant xenophagy and propose a unifying framework in which xenophagy appears to function as a cell\u2010autonomous immune hub comprising three interconnected modules: cargo recognition, selective sequestration, and autophagic execution, dynamically modulated by pathogen\u2010derived countermeasures. We further examine how pathogens subvert or exploit host autophagic machinery, revealing xenophagy as a contested interface in plant\u2010pathogen interactions. By integrating molecular, cellular, and cross\u2010kingdom perspectives, we highlight key conceptual gaps, including the specificity of cargo selection, the regulatory logic of receptor engagement, and the coordination between autophagy and canonical immune pathways. Resolving these gaps will be essential for repositioning xenophagy as a central determinant of plant immune competence, with significant implications for engineering disease\u2010resistant crops.<\/jats:p>","DOI":"10.1111\/pce.70830","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:41:26Z","timestamp":1788262886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Selective Autophagy in Plant Immunity: Mechanisms, Regulation, and Emerging Concepts in Xenophagy"],"prefix":"10.1111","author":[{"given":"Laha","family":"Supriya","sequence":"first","affiliation":[{"name":"Department of Plant Sciences, School of Life Sciences University of Hyderabad Hyderabad Telangana India"},{"name":"BRIC\u2010Institute of Life Sciences, Nalco Square Bhubaneswar Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Dake","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences, School of Life Sciences University of Hyderabad Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8382-0583","authenticated-orcid":false,"given":"Pooja","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences, School of Life Sciences University of Hyderabad Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namisha","family":"Sharma","sequence":"additional","affiliation":[{"name":"BRIC\u2010Institute of Life Sciences, Nalco Square Bhubaneswar Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1658-7013","authenticated-orcid":false,"given":"Padmaja","family":"Gudipalli","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences, School of Life Sciences University of Hyderabad Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7589-6372","authenticated-orcid":false,"given":"Mehanathan","family":"Muthamilarasan","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences, School of Life Sciences University of Hyderabad Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1105\/tpc.108.060996","article-title":"Atg26\u2010Mediated Pexophagy Is Required for Host Invasion by the Plant Pathogenic Fungus Colletotrichum orbiculare","volume":"21","author":"Asakura M.","year":"2009","journal-title":"Plant Cell"},{"key":"e_1_2_14_3_1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.pbi.2016.12.004","article-title":"Shaping Plant Development Through the SnRK1\u2013TOR Metabolic Regulators","volume":"35","author":"Baena\u2010Gonz\u00e1lez E.","year":"2017","journal-title":"Current Opinion in Plant Biology"},{"key":"e_1_2_14_4_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1105\/tpc.18.00872","article-title":"Plant Extracellular Vesicles Contain Diverse Small RNA Species and Are Enriched in 10\u2010 to 17\u2010Nucleotide \u201cTiny\u201d RNAs","volume":"31","author":"Baldrich P.","year":"2019","journal-title":"Plant Cell"},{"key":"e_1_2_14_5_1","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.pbi.2007.06.006","article-title":"Plant Autophagy\u2014More Than a Starvation Response","volume":"10","author":"Bassham D. 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