{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:48:56Z","timestamp":1787323736506,"version":"build-2736575974"},"reference-count":70,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004189","name":"Max-Planck-Gesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["508398975\/Fe"],"award-info":[{"award-number":["508398975\/Fe"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Cell &amp;amp; Environment"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Photorespiration secures oxygenic photosynthesis from metabolic constraints arising from the oxygenation reaction of Rubisco in today's oxygen\u2010rich atmosphere. Beyond this protective function, it is vital for primary metabolism, cellular redox balance, and stomatal regulation. Importantly, photorespiration has emerged as a key target for improving CO\n                    <jats:sub>2<\/jats:sub>\n                    assimilation and biomass production. Among proposed strategies, enhancing photorespiratory efficiency via upregulation of core enzymes has highlighted glycine decarboxylase (GDC) as a promising target, however, it remains unclear whether simultaneous upregulation of multiple GDC components would yield additive or synergistic improvements in plant environmental acclimation. Here, we systematically compared single and double GDC overexpression lines under varying photoperiods, elevated oxygen and high light. GDC upregulation consistently promoted growth across photoperiods and enhanced photosynthetic performance under high light and oxygen, indicating a severe benefit of increased photorespiratory metabolite conversion. Notably, double overexpression lines exhibited enhanced metabolic flexibility beyond that observed in single lines, supporting synergistic effects on carbon assimilation and allocation. Short\u2010term high\u2010light exposure further revealed increased Rubisco activity and efficient partitioning of carbon into sucrose and starch. Collectively, our results demonstrate that coordinated enhancement of GDC activity strengthens photorespiratory efficiency and can generate synergistic improvements in photosynthetic robustness, metabolic robustness, and environmental acclimation under stressful conditions. These findings position multicomponent GDC engineering as a promising strategy for developing crops with improved environmental acclimation capacity.\n                  <\/jats:p>","DOI":"10.1111\/pce.70836","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:12:48Z","timestamp":1787321568000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi\u2010Subunit Engineering of Photorespiratory Glycine Decarboxylase Refines Photosynthesis, Growth and Metabolic Robustness of\n                    <i>Arabidopsis<\/i>"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2027-5444","authenticated-orcid":false,"given":"Hu","family":"Sun","sequence":"first","affiliation":[{"name":"University of Rostock, Plant Physiology Department Albert\u2010Einstein\u2010Stra\u00dfe 3 Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannic C. R.","family":"Wagner","sequence":"additional","affiliation":[{"name":"University of Rostock, Plant Physiology Department Albert\u2010Einstein\u2010Stra\u00dfe 3 Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wieke\u2010Marie","family":"Rosenfeldt","sequence":"additional","affiliation":[{"name":"University of Rostock, Plant Physiology Department Albert\u2010Einstein\u2010Stra\u00dfe 3 Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0605-3379","authenticated-orcid":false,"given":"Rhena","family":"Schumann","sequence":"additional","affiliation":[{"name":"Biological Station Zingst, University of Rostock Zingst Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0516-6950","authenticated-orcid":false,"given":"St\u00e9phanie","family":"Arrivault","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Molecular Plant Physiology, Am M\u00fchlenberg 1 Golm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1748-9473","authenticated-orcid":false,"given":"Guillaume","family":"Decros","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Molecular Plant Physiology, Am M\u00fchlenberg 1 Golm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8144-4604","authenticated-orcid":false,"given":"Rhiannon","family":"Page","sequence":"additional","affiliation":[{"name":"Lancaster Environment Centre, Lancaster University LA1 Lancaster UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6059-9359","authenticated-orcid":false,"given":"Elizabete Carmo","family":"Silva","sequence":"additional","affiliation":[{"name":"Lancaster Environment Centre, Lancaster University LA1 Lancaster UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4073-7221","authenticated-orcid":false,"given":"Tracy","family":"Lawson","sequence":"additional","affiliation":[{"name":"University of Essex, Wivenhoe Park Colchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1854-6995","authenticated-orcid":false,"given":"Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Forest Ecosystem Stability and Global Change, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences Mengla Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9000-335X","authenticated-orcid":false,"given":"Alisdair R.","family":"Fernie","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Molecular Plant Physiology, Am M\u00fchlenberg 1 Golm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7802-8925","authenticated-orcid":false,"given":"Hermann","family":"Bauwe","sequence":"additional","affiliation":[{"name":"University of Rostock, Plant Physiology Department Albert\u2010Einstein\u2010Stra\u00dfe 3 Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2059-2061","authenticated-orcid":false,"given":"Martin","family":"Hagemann","sequence":"additional","affiliation":[{"name":"University of Rostock, Plant Physiology Department Albert\u2010Einstein\u2010Stra\u00dfe 3 Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3105-6296","authenticated-orcid":false,"given":"Stefan","family":"Timm","sequence":"additional","affiliation":[{"name":"University of Rostock, Plant Physiology Department Albert\u2010Einstein\u2010Stra\u00dfe 3 Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0005-2744(71)90051-9","article-title":"Chloroplast and Cytoplasmic Enzymes. 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P.","year":"2025","journal-title":"Cell"},{"key":"e_1_2_9_38_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/pbi.12953","article-title":"Overexpressing the H\u2010Protein of the Glycine Cleavage System Increases Biomass Yield in Glasshouse and Field\u2010Grown Transgenic Tobacco Plants","volume":"17","author":"L\u00f3pez\u2010Calcagno P. E.","year":"2019","journal-title":"Plant Biotechnology Journal"},{"key":"e_1_2_9_39_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fpls.2012.00038","article-title":"Transgenic Introduction of a Glycolate Oxidative Cycle Into A. thaliana Chloroplasts Leads to Growth Improvement","volume":"3","author":"Maier A.","year":"2012","journal-title":"Frontiers in Plant Science"},{"key":"e_1_2_9_40_1","doi-asserted-by":"crossref","DOI":"10.1111\/gcb.17595","article-title":"Shortcutting Photorespiration Protects Potato Photosynthesis and Tuber Yield Against Heatwave Stress","volume":"30","author":"Meacham\u2010Hensold K.","year":"2024","journal-title":"Global Change Biology"},{"key":"e_1_2_9_41_1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/nph.70724","article-title":"Shortcutting Photorespiration: Avenues and Challenges Toward Realizing Higher\u2010Yielding Photorespiratory Bypass Crops","volume":"249","author":"Meacham\u2010Hensold K.","year":"2026","journal-title":"New Phytologist"},{"key":"e_1_2_9_42_1","first-page":"643","article-title":"High Serine: Glyoxylate Aminotransferase Activity Lowers Leaf Daytime Serine Levels, Inducing the Phosphoserine Pathway in Arabidopsis","volume":"68","author":"Modde K.","year":"2017","journal-title":"Journal of Experimental Botany"},{"key":"e_1_2_9_43_1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1365-313X.2004.02311.x","article-title":"Arabidopsis SHMT1, a Serine Hydroxymethyltransferase That Functions in the Photorespiratory Pathway Influences Resistance to Biotic and Abiotic Stress","volume":"41","author":"Moreno J. I.","year":"2005","journal-title":"Plant Journal"},{"key":"e_1_2_9_44_1","doi-asserted-by":"crossref","first-page":"5315","DOI":"10.1111\/pce.15097","article-title":"Carboxylation Capacity Is the Main Limitation of Carbon Assimilation in High Arctic Shrubs","volume":"47","author":"Paillassa J.","year":"2024","journal-title":"Plant, Cell & Environment"},{"key":"e_1_2_9_45_1","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1073\/pnas.1215142110","article-title":"PLGG1, a Plastidic Glycolate Glycerate Transporter, Is Required for Photorespiration and Defines a Unique Class of Metabolite Transporters","volume":"110","author":"Pick T. 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