{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:13:59Z","timestamp":1788329639788,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32302583"],"award-info":[{"award-number":["32302583"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Cell &amp; Environment"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Maintaining cellular photosensitivity while preventing damage from excessive light energy is a crucial challenge for plants, and negative feedback inhibition of photoreceptors plays a vital role in achieving this balance. Here, we uncover a regulatory mechanism involved in the UVR8\u2010mediated UV\u2010B signalling pathway. Through a combination of genetic, biochemical and cross\u2010species analyses, we identified Arabidopsis BIC1 and BIC2, along with their orthologs in eggplant (\n                    <jats:italic>Solanum melongena<\/jats:italic>\n                    L.), as functionally conserved negative regulators in UV\u2010B signalling. Through physical association with UVR8, BIC proteins likely stabilise its inactive dimeric state, which in turn attenuates UV\u2011B\u2011triggered monomerization and downstream transcriptional activation of the photoreceptor. Overexpression of BIC proteins in both eggplant and Arabidopsis promote hypocotyl elongation under UV\u2010B, while the\n                    <jats:italic>bic1bic2<\/jats:italic>\n                    double mutant exhibits enhanced photomorphogenesis. Notably, the\n                    <jats:italic>uvr8\u20106bic1bic2<\/jats:italic>\n                    triple mutant displays an intermediate phenotype between the\n                    <jats:italic>uvr8\u20106<\/jats:italic>\n                    and\n                    <jats:italic>bic1bic2<\/jats:italic>\n                    parents, revealing a mutual regulatory relationship: BIC proteins inhibit UVR8 activity at the protein level, while UVR8 promotes\n                    <jats:italic>BIC<\/jats:italic>\n                    transcription via HY5. Heterologous overexpression of eggplant SmBIC proteins in Arabidopsis phenocopies the elongated hypocotyl phenotype of Arabidopsis BIC\u2010overexpressors, further supporting functional conservation. Mechanistically, BICs attenuate UVR8\u2010dependent transcriptional activation of\n                    <jats:italic>HY5<\/jats:italic>\n                    without directly binding to the\n                    <jats:italic>HY5<\/jats:italic>\n                    promoter. We establish a self\u2010regulatory negative feedback loop in which HY5 activates\n                    <jats:italic>BIC<\/jats:italic>\n                    expression upon UV\u2010B exposure, and BICs reciprocally suppress UVR8\u2010mediated\n                    <jats:italic>HY5<\/jats:italic>\n                    transactivation by stabilising the UVR8 dimer. This non\u2010proteolytic regulatory circuit enables precise fine\u2010tuning of photomorphogenic responses to fluctuating UV\u2010B environments. Our study expands the functional repertoire of BIC proteins beyond blue light signalling and defines a conserved mechanism for attenuating UV\u2010B responses essential for environmental adaptation in terrestrial plants.\n                  <\/jats:p>","DOI":"10.1111\/pce.70855","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:32:07Z","timestamp":1788327127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional Conservation of BIC\u2010UVR8\u2010Mediated Suppression of UV\u2010B Responses in Arabidopsis and Eggplant"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3220-685X","authenticated-orcid":false,"given":"Yong\u2010jun","family":"He","sequence":"first","affiliation":[{"name":"School of Life Sciences Anhui Agricultural University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9697-1819","authenticated-orcid":false,"given":"Jin\u2010di","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences Anhui Agricultural University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6006-8216","authenticated-orcid":false,"given":"Meng\u2010yao","family":"Duan","sequence":"additional","affiliation":[{"name":"School of Life Sciences Anhui Agricultural University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9133-2494","authenticated-orcid":false,"given":"Long\u2010qi","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Life Sciences Anhui Agricultural University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1235-1214","authenticated-orcid":false,"given":"Chen","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Life Sciences Anhui Agricultural University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"18225","DOI":"10.1073\/pnas.0507187102","article-title":"A UV\u2010B\u2010Specific Signaling Component Orchestrates Plant UV Protection","volume":"102","author":"Brown B. 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J.","year":"2009","journal-title":"EMBO Journal"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"20132","DOI":"10.1073\/pnas.0914532107","article-title":"Negative Feedback Regulation of UV\u2010B\u2010Induced Photomorphogenesis and Stress Acclimation in Arabidopsis","volume":"107","author":"Gruber H.","year":"2010","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1093\/pcp\/pcab070","article-title":"SmBICs Inhibit Anthocyanin Biosynthesis in Eggplant (Solanum melongena L.)","volume":"62","author":"He Y.","year":"2021","journal-title":"Plant and Cell Physiology"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1073\/pnas.1214237110","article-title":"Reversion of the Arabidopsis UV\u2010B Photoreceptor UVR8 to the Homodimeric Ground State","volume":"110","author":"Heijde M.","year":"2013","journal-title":"Proceedings of the National Academy of 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