{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:17:55Z","timestamp":1788239875065,"version":"build-2803163510"},"reference-count":62,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20463"],"award-info":[{"award-number":["U22A20463"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872926"],"award-info":[{"award-number":["31872926"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Cell &amp;amp; Environment"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Understanding the molecular mechanisms underlying plant responses to various stresses is crucial for improving crop productivity under stressful conditions. However, how plants prioritize the activation of pathways to balance disease resistance with drought and salt tolerance remains unclear. Here, we identify two regulatory modules centered on the rice protein OsSRLD, which negatively regulates disease resistance and positively regulates drought\/salt tolerance. Upregulation of\n                    <jats:italic>OsSRLD<\/jats:italic>\n                    increases ABA content and reduces ROS levels under both normal and stressed conditions, suggesting its involvement in ABA signaling and ROS homeostasis. As an E3 ligase, OsSRLD interacts with OsIM\u03b11a (a positive regulator of disease resistance) and promotes its ubiquitination and degradation via the 26S proteasome. Additionally, OsIM\u03b11a interacts with OsWRKY53 (a positive regulator of disease resistance but a negative regulator of salt tolerance), thereby promoting the nuclear accumulation of OsWRKY53. Consistently, both overexpression of\n                    <jats:italic>OsSRLD<\/jats:italic>\n                    and knockout of\n                    <jats:italic>OsIM\u03b11a<\/jats:italic>\n                    resulted in downregulation of OsWRKY53\u2010activated genes and upregulation of OsWRKY53\u2010inactivated genes. Furthermore, OsSRLD interacts with and stabilizes OsDIP1 (a positive regulator of drought and salt tolerance) via an E3 ligase\u2010independent pathway. Together, our findings reveal that OsSRLD\u2010OsIM\u03b11a\u2010OsWRKY53 and OsSRLD\u2010OsDIP1 modules balance disease resistance and drought\/salt tolerance through both E3 ligase\u2010dependent and E3 ligase\u2010independent pathways.\n                  <\/jats:p>","DOI":"10.1111\/pce.70856","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:42:10Z","timestamp":1788237730000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The OsSRLD\u2010OsIM\u03b11a\u2010OsWRKY53 and OsSRLD\u2010OsDIP1 Modules Balance Disease Resistance and Drought\/Salt Tolerance in Rice"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7471-4403","authenticated-orcid":false,"given":"Yapu","family":"Cheng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity China Agricultural University Beijing People's Republic of 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