{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:09:23Z","timestamp":1790143763098,"version":"4.0.1"},"reference-count":73,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 2048\/1 \u2013 390686111"],"award-info":[{"award-number":["EXC 2048\/1 \u2013 390686111"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK 2466 \u2013 F020512056"],"award-info":[{"award-number":["GRK 2466 \u2013 F020512056"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR 341\/1 \u2013 456082119"],"award-info":[{"award-number":["TRR 341\/1 \u2013 456082119"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG\u2010INST 208\/551\u20101 FUGG"],"award-info":[{"award-number":["DFG\u2010INST 208\/551\u20101 FUGG"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG\u2010INST 208\/746\u20101 FUGG"],"award-info":[{"award-number":["DFG\u2010INST 208\/746\u20101 FUGG"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Cell &amp;amp; Environment"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Iron (Fe) homeostasis is regulated to prevent iron imbalance, with the help of redundant basic helix\u2010loop\u2010helix (bHLH) IVc transcription factors that can be controlled by Fe\u2010binding E3 ligases such as BRUTUS (BTS) in\n                    <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                    . However, knowledge gaps remain to fully explain the mechanistic basis of this redundant protein interaction module. The C\u2010terminus of bHLH104 is known to interact with BTS, and structural predictions implicate the three terminal amino acids, proline\u2010alanine\u2010alanine (PAA). However, the importance of the PAA sequence for post\u2010translational regulation of bHLH104 and for the resulting plant phenotypes has not been tested experimentally. Here we show that transgenic plants expressing a bHLH104 variant lacking PAA (b104^dPAA) constitutively upregulate Fe acquisition and Fe transport genes and accumulate Fe, whereas plants expressing wild\u2010type bHLH104 do not. The extent of Fe accumulation in independent b104^dPAA lines correlated positively with b104^dPAA protein abundance. Unlike the wild\u2010type form, b104^dPAA showed no indication of interaction with BTS or of ubiquitination by it. Together, these findings support a model in which the PAA sequence serves as a recognition motif for binding to BTS and for subsequent post\u2010translational regulation of bHLH104. Hence, targeted manipulation of the bHLH IVc protein PAA sequence may represent a strategy for crop biofortification.\n                  <\/jats:p>","DOI":"10.1111\/pce.70879","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:38:47Z","timestamp":1790141927000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Three Amino Acid Sequence Gates Protein Stability Control of bHLH104 and Iron Uptake in\n                    <i>Arabidopsis thaliana<\/i>"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0592-6067","authenticated-orcid":false,"given":"Dibin","family":"Baby","sequence":"first","affiliation":[{"name":"Institute of Botany, Heinrich Heine University D\u00fcsseldorf Germany"},{"name":"Cluster of Excellence on Plant Science (CEPLAS) Heinrich Heine University D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Weldi","sequence":"additional","affiliation":[{"name":"Institute of Botany, Heinrich Heine University D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Knopf","sequence":"additional","affiliation":[{"name":"Institute of Botany, Heinrich Heine University D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinitha","family":"Venkadasamy","sequence":"additional","affiliation":[{"name":"Institute of Botany, Heinrich Heine University D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica Lee","family":"Erickson","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Molekularbiologie der Pflanzen (ZMBP), Allgemeine Genetik University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0404-4532","authenticated-orcid":false,"given":"Petra","family":"Bauer","sequence":"additional","affiliation":[{"name":"Institute of Botany, Heinrich Heine University D\u00fcsseldorf Germany"},{"name":"Cluster of Excellence on Plant Science (CEPLAS) Heinrich Heine University D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate Structure Prediction of Biomolecular Interactions With AlphaFold 3","volume":"630","author":"Abramson J.","year":"2024","journal-title":"Nature"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s00425-022-04018-7","article-title":"Birth, Life and Death of the Arabidopsis IRT1 Iron Transporter: The Role of Close Friends and Foes","volume":"256","author":"Abuzeineh A.","year":"2022","journal-title":"Planta"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/mpp.12388","article-title":"The Coat Protein of Alfalfa mosaic virus Interacts and Interferes With the Transcriptional Activity of the bHLH Transcription Factor ILR3 Promoting Salicylic Acid\u2010Dependent Defence Signalling Response","volume":"18","author":"Aparicio F.","year":"2017","journal-title":"Molecular Plant Pathology"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.pbi.2007.04.003","article-title":"Iron Utilization and Metabolism in Plants","volume":"10","author":"Briat J.\u2010F.","year":"2007","journal-title":"Current Opinion in Plant Biology"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1105\/tpc.109.073023","article-title":"High\u2010Affinity Manganese Uptake by the Metal Transporter NRAMP1 Is Essential for Arabidopsis Growth in Low Manganese Conditions","volume":"22","author":"Cailliatte R.","year":"2010","journal-title":"Plant Cell"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1104\/pp.112.212068","article-title":"Iron Is Involved in the Maintenance of Circadian Period Length in Arabidopsis","volume":"161","author":"Chen Y.\u2010Y.","year":"2013","journal-title":"Plant Physiology"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1242\/dev.00992","article-title":"Gibberellin Regulates Arabidopsis Floral Development via Suppression of DELLA Protein Function","volume":"131","author":"Cheng H.","year":"2004","journal-title":"Development"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1046\/j.1365-313x.1998.00343.x","article-title":"Floral Dip: A Simplified Method for Agrobacterium\u2010Mediated Transformation of Arabidopsis thaliana","volume":"16","author":"Clough S. 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