{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:09:45Z","timestamp":1790143785800,"version":"4.0.1"},"reference-count":63,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Sv. 922\/18"],"award-info":[{"award-number":["Sv. 922\/18"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013371","name":"Universit\u00e9 C\u00f4te d\u2019Azur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013371","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Cell &amp;amp; Environment"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The anaphase\u2010promoting complex\/cyclosome (APC\/C) is a multi\u2010subunit E3 ubiquitin ligase that regulates cell cycle progression, but its role in plant\u2010pathogen interactions is poorly understood. Here, we demonstrate that regulation of the ubiquitin\u2013proteasome system, involving APC\/C\u2010associated components, is critical for coordinating host cell cycle modulation and cellular homoeostasis required for proper gall formation and successful nematode parasitism. Inhibition of the 26S proteasome with MG132 severely disrupted gall morphology and nematode development, indicating that proteasome activity is required for feeding site establishment and maintenance. To assess the contribution of APC\/C associated components involved in proteasome\u2010mediated degradation, we examined the effects of overexpressing\n                    <jats:italic>APC5<\/jats:italic>\n                    ,\n                    <jats:italic>APC7<\/jats:italic>\n                    and\n                    <jats:italic>APC10<\/jats:italic>\n                    during interactions with the root\u2010knot nematode\n                    <jats:italic>Meloidogyne incognita<\/jats:italic>\n                    and the oomycete\n                    <jats:italic>Hyaloperonospora arabidopsidis<\/jats:italic>\n                    (Hpa). Overexpression of a truncated\n                    <jats:italic>APC7<\/jats:italic>\n                    variant (\n                    <jats:italic>APC7\u2010CT<\/jats:italic>\n                    <jats:sup>OE<\/jats:sup>\n                    ), conferred strong resistance to both pathogens, reducing nematode egg mass production by 81% and Hpa conidiospore production by 97%.\n                    <jats:italic>APC7\u2010CT<\/jats:italic>\n                    <jats:sup>OE<\/jats:sup>\n                    plants exhibited altered gall morphology, suggesting premature senescence of giant cells. In contrast, overexpression of\n                    <jats:italic>APC5<\/jats:italic>\n                    or\n                    <jats:italic>APC10<\/jats:italic>\n                    increased susceptibility to\n                    <jats:italic>M. incognita<\/jats:italic>\n                    , revealing functional divergence among APC\/C components. Our findings identify a previously unrecognised role for APC\/C\u2010related regulatory pathways in regulating host cellular processes that influence pathogen success and highlight APC7\u2010CT as a potential target for improving resistance to diverse pathogens.\n                  <\/jats:p>","DOI":"10.1111\/pce.70884","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:46:25Z","timestamp":1790142385000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modulation of Anaphase\u2010Promoting Complex Genes Regulates Root\u2010Knot Nematode Gall Development and Plant Susceptibility"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5723-7696","authenticated-orcid":false,"given":"Aline K\u00f6hn","family":"Carneiro","sequence":"first","affiliation":[{"name":"INRAE Universit\u00e9 C\u00f4te d'Azur, CNRS Sophia Antipolis France"},{"name":"Laborat\u00f3rio de Biologia Molecular de Plantas, Instituto de Bioqu\u00edmica M\u00e9dica Universidade Federal do Rio de Janeiro Cidade Universit\u00e1ria Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0161-9393","authenticated-orcid":false,"given":"K\u00e9rcya Maria Sim\u00f5es de","family":"Siqueira","sequence":"additional","affiliation":[{"name":"INRAE Universit\u00e9 C\u00f4te d'Azur, CNRS Sophia Antipolis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6844-8296","authenticated-orcid":false,"given":"La Hoang","family":"Anh","sequence":"additional","affiliation":[{"name":"INRAE Universit\u00e9 C\u00f4te d'Azur, CNRS Sophia Antipolis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5717-4974","authenticated-orcid":false,"given":"Sophie","family":"Pagnotta","sequence":"additional","affiliation":[{"name":"Universit\u00e9 C\u00f4te d'Azur, Centre Commun de Microscopie Appliqu\u00e9e (CCMA) Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1823-9135","authenticated-orcid":false,"given":"Danila Cabral do","family":"Nascimento","sequence":"additional","affiliation":[{"name":"INRAE Universit\u00e9 C\u00f4te d'Azur, CNRS Sophia Antipolis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8380-5063","authenticated-orcid":false,"given":"Nubia Barbosa","family":"Eloy","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Escola Superior de Agricultura \u201cLuiz de Queiroz\u201d Universidade de S\u00e3o Paulo Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1243-8467","authenticated-orcid":false,"given":"Harald","family":"Keller","sequence":"additional","affiliation":[{"name":"INRAE Universit\u00e9 C\u00f4te d'Azur, CNRS Sophia Antipolis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3748-7118","authenticated-orcid":false,"given":"Adriana Silva","family":"Hemerly","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Molecular de Plantas, Instituto de Bioqu\u00edmica M\u00e9dica Universidade Federal do Rio de Janeiro Cidade Universit\u00e1ria Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8312-672X","authenticated-orcid":false,"given":"Janice de Almeida","family":"Engler","sequence":"additional","affiliation":[{"name":"INRAE Universit\u00e9 C\u00f4te d'Azur, CNRS Sophia Antipolis France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u2010313X.2012.05054.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u2010313X.2004.02022.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4322\/nematoda.00616"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.abr.2014.12.003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.11.5.793"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2017.00961"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pce.15248"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1094\/mpmi\u201009\u201023\u20100124\u2010fi"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.16185"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2021.636663"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants10091804"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u2010313x.1999.00620.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.13251"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/eru097"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI\u201007\u201015\u20100146\u2010R"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants10020246"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants10050928"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.5.17.3125"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u2010313X.2011.04691.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/07352689.2015.1078613"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00010\u201015"},{"issue":"1","key":"e_1_2_11_23_1","first-page":"63","article-title":"Contribution of Nematodes to the Structure and Function of the Soil Food Web","volume":"42","author":"Ferris H.","year":"2010","journal-title":"Journal of Nematology"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09625"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.990120702"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants15030506"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erv128"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101418\u20106"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00425\u2010017\u20102727\u20103"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2021.800030"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/mpp.12057"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1590\/fst.52420"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.111.177568"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010217"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2021036118"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41477\u2010019\u20100358\u20103"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xplc.2020.100020"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/ery204"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2017.01815"},{"key":"e_1_2_11_40_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-94-007-0434-3_2","volume-title":"Genomics and Molecular Genetics of Plant\u2010Nematode Interactions","author":"Nicol J. M.","year":"2011"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.70066"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1988"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20160152"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2017.00899"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2021.642934"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592\u2010023\u201001987\u20109"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09756"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2021.563760"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/OT9.0000000000000119"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010arplant\u2010080720\u2010103739"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.12.3839"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.17810"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2018.09.014"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.114.126086"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20108137.2012.04171.x"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.12255"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2019.02.007"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010cellbio\u2010120420\u2010092421"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.4161\/psb.5.2.10526"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.109.138321"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gecco.2020.e01118"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4202"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erz348"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plantsci.2022.111344"}],"container-title":["Plant, Cell &amp; Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pce.70884","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pce.70884","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pce.70884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:46:27Z","timestamp":1790142387000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pce.70884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":63,"alternative-id":["10.1111\/pce.70884"],"URL":"https:\/\/doi.org\/10.1111\/pce.70884","archive":["Portico"],"relation":{},"ISSN":["0140-7791","1365-3040"],"issn-type":[{"value":"0140-7791","type":"print"},{"value":"1365-3040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,22]]},"assertion":[{"value":"2026-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"pce.70884"}}