{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:00:44Z","timestamp":1790002844222,"version":"4.0.1"},"reference-count":71,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["2021\u201012930"],"award-info":[{"award-number":["2021\u201012930"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Cell &amp; Environment"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Aluminum (Al) toxicity in acidic soils is a major constraint on global crop production, inhibiting root growth, and disrupting redox homeostasis. In this study, we identify the RING\/U\u2010box E3 ubiquitin ligase (RUB) as a regulator associated with Al responses in\n                    <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                    through genome\u2010wide association analysis (GWAS) across eight root architectural traits. Functional characterization of\n                    <jats:italic>rub<\/jats:italic>\n                    T\u2010DNA mutants and RUB overexpression (OE) lines demonstrated RUB functions as a positive regulator of Al\u2010induced inhibition of root growth and oxidative stress, with\n                    <jats:italic>rub<\/jats:italic>\n                    mutants exhibiting enhanced root growth, decreased Al accumulation, reduced reactive oxygen species (ROS) levels and DNA damage while OE lines showed impaired root architecture growth, increased Al retention in root tips, elevated oxidative stress and DNA damage. Transcriptomic analysis of transgenic lines further revealed differential expression of genes associated with four major biological processes: MAPK signaling, hormonal signaling, root hair and lateral root development, and the oxidative stress response, suggesting coordinated stress response mechanisms. Overall, this study provides new insights into plant adaptation to Al stress and establishes a foundation for future studies investigating the molecular role and downstream targets of RUB.\n                  <\/jats:p>","DOI":"10.1111\/pce.70892","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:06:22Z","timestamp":1789999582000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["RUB\u2010Associated Regulation of Aluminum Sensitivity Reveals a New Layer of Aluminum Stress Signaling in Arabidopsis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0577-1176","authenticated-orcid":false,"given":"Vandana","family":"Thakral","sequence":"first","affiliation":[{"name":"Gus R. Douglass Institute, Department of Biology West Virginia State University Institute West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun Ojha","family":"Kshetry","sequence":"additional","affiliation":[{"name":"Gus R. Douglass Institute, Department of Biology West Virginia State University Institute West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6903-9478","authenticated-orcid":false,"given":"Shyam","family":"Gundu","sequence":"additional","affiliation":[{"name":"Gus R. Douglass Institute, Department of Biology West Virginia State University Institute West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2902-2281","authenticated-orcid":false,"given":"Sarai","family":"Cook","sequence":"additional","affiliation":[{"name":"Gus R. Douglass Institute, Department of Biology West Virginia State University Institute West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5834-6499","authenticated-orcid":false,"given":"Suhas","family":"Shinde","sequence":"additional","affiliation":[{"name":"Gus R. Douglass Institute, Department of Biology West Virginia State University Institute West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahamkali VS Sai","family":"Subhash","sequence":"additional","affiliation":[{"name":"Gus R. Douglass Institute, Department of Biology West Virginia State University Institute West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5505-7109","authenticated-orcid":false,"given":"Purushothaman","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Gus R. Douglass Institute, Department of Biology West Virginia State University Institute West Virginia USA"},{"name":"Department of Agriculture, Food and Resource Sciences University of Maryland Eastern Shore Princess Anne Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8464-605X","authenticated-orcid":false,"given":"Carlos","family":"L\u00f3pez\u2010Ortiz","sequence":"additional","affiliation":[{"name":"Gus R. Douglass Institute, Department of Biology West Virginia State University Institute West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0601-2315","authenticated-orcid":false,"given":"Neha","family":"Boora","sequence":"additional","affiliation":[{"name":"Gus R. Douglass Institute, Department of Biology West Virginia State University Institute West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9641-2314","authenticated-orcid":false,"given":"Subramanyam Reddy","family":"Chinreddy","sequence":"additional","affiliation":[{"name":"Gus R. Douglass Institute, Department of Biology West Virginia State University Institute West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste","family":"Gracia\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Gus R. Douglass Institute, Department of Biology West Virginia State University Institute West Virginia USA"},{"name":"Laboratorio de Biorremediaci\u00f3n, Facultad de Ciencias Biol\u00f3gicas Universidad Aut\u00f3noma de Coahuila Torre\u00f3n Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan Chavez\u2010Hita","family":"Wong","sequence":"additional","affiliation":[{"name":"Gus R. Douglass Institute, Department of Biology West Virginia State University Institute West Virginia USA"},{"name":"Laboratorio de Biorremediaci\u00f3n, Facultad de Ciencias Biol\u00f3gicas Universidad Aut\u00f3noma de Coahuila Torre\u00f3n Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7818-2818","authenticated-orcid":false,"given":"Nagamani","family":"Balagurusamy","sequence":"additional","affiliation":[{"name":"Laboratorio de Biorremediaci\u00f3n, Facultad de Ciencias Biol\u00f3gicas Universidad Aut\u00f3noma de Coahuila Torre\u00f3n Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2570-9193","authenticated-orcid":false,"given":"Padma","family":"Nimmakayala","sequence":"additional","affiliation":[{"name":"Gus R. 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