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We propose three strategies\u2014targeting conserved host nodes, synergizing S gene knockout with R gene pyramiding and tailored precision editing\u2014to achieve broad\u2010spectrum resistance without yield penalties.<\/jats:p>","DOI":"10.1111\/pce.70907","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:36:04Z","timestamp":1790141764000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Editing Susceptibility Genes for Broad\u2010Spectrum Resistance in Plants: From Passive Knockout to Active Design"],"prefix":"10.1111","author":[{"given":"Qing","family":"Chen","sequence":"first","affiliation":[{"name":"College of Life Sciences Yantai University Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0804-190X","authenticated-orcid":false,"given":"Jun","family":"Guo","sequence":"additional","affiliation":[{"name":"Crop Research Institute Shandong Academy of Agricultural Sciences Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianying","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Life Sciences Yantai University Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongdun","family":"Xie","sequence":"additional","affiliation":[{"name":"Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2777-0705","authenticated-orcid":false,"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life Sciences Yantai University Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.12631"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pce.15174"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pce.15021"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jipb.13901"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.06.027"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03316-6"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-026-10273-5"}],"container-title":["Plant, Cell &amp; Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pce.70907","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pce.70907","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pce.70907","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:36:05Z","timestamp":1790141765000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pce.70907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":7,"alternative-id":["10.1111\/pce.70907"],"URL":"https:\/\/doi.org\/10.1111\/pce.70907","archive":["Portico"],"relation":{},"ISSN":["0140-7791","1365-3040"],"issn-type":[{"value":"0140-7791","type":"print"},{"value":"1365-3040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,22]]},"assertion":[{"value":"2026-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"pce.70907"}}