{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:53:10Z","timestamp":1791175990839,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQN25C140003"],"award-info":[{"award-number":["LQN25C140003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32402386"],"award-info":[{"award-number":["32402386"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Cell &amp; Environment"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The leaf\u2010mining insect\n                    <jats:italic>Tuta absoluta<\/jats:italic>\n                    is a highly destructive pest that deploys candidate effector proteins to modulate host defences; however, the molecular mechanisms underlying this manipulation remain poorly understood. In this study, we characterise TaCYPE1, a predicted secreted cyclophilin\u2010like effector, and demonstrate its role in promoting insect virulence. Transient expression of TaCYPE1 in\n                    <jats:italic>Nicotiana benthamiana<\/jats:italic>\n                    suppresses pattern\u2010triggered immunity (PTI), including INF1\u2010induced cell death, reactive oxygen species (ROS) burst, and defence\u2010related gene expression. Notably, this immune suppression occurs independently of the conserved peptidyl\u2010prolyl cis\u2010trans isomerase (PPIase) activity of TaCYPE1. Stable overexpression of TaCYPE1 in tomato increases host susceptibility and enhances larval feeding, confirming its virulence function in a crop host. Mechanistically, TaCYPE1 physically interacts with host glycine\u2010rich RNA\u2010binding proteins (GR\u2010RBPs), including SlRBP1 in tomato and NbRBGA in\n                    <jats:italic>N. benthamiana<\/jats:italic>\n                    , the latter contributes positively to selected immune responses and anti\u2010herbivore defence. Domain\u2010mapping analyses reveal that TaCYPE1 interacts with the conserved RNA\u2010recognition motifs (RRMs) of GR\u2010RBPs, and similar interactions are observed among GR\u2010RBP homologues in solanaceous plants. Collectively, our findings identify TaCYPE1 as a virulence\u2010associated factor that attenuates plant immunity through targeting GR\u2010RBP\u2010mediated regulatory processes, revealing a previously unrecognised layer of post\u2010transcriptional modulation in plant\u2013insect interactions.\n                  <\/jats:p>","DOI":"10.1111\/pce.70944","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:40:27Z","timestamp":1791175227000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Cyclophilin Effector TaCYPE1 From the Tomato Leaf Miner\n                    <i>Tuta absoluta<\/i>\n                    Suppresses Plant Immunity by Targeting Host RNA\u2010Binding Proteins"],"prefix":"10.1111","author":[{"given":"Zhili","family":"Zhao","sequence":"first","affiliation":[{"name":"College of Life and Environmental Sciences Hangzhou Normal University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Sciences Hangzhou Normal University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Pu","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Sciences Hangzhou Normal University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangqian","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Sciences Hangzhou Normal University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3263-8792","authenticated-orcid":false,"given":"Yumei","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Sciences Hangzhou Normal University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Sciences Hangzhou Normal University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/arch.22056"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.2c08650"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009388"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088090"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.142548"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.2673"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-022-01261-5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi049490o"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1905471116"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants12193504"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2020.00451"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05335.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000439"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232315337"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10340-010-0321-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2022.912603"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/eraa015"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2026.104500"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.18675"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molp.2018.05.009"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2021.12.010"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202409186"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05737"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2025.110358"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2011.05.003"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jipb.12438"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005139"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/mpp.13416"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.17573"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12374-026-09506-x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115849"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/plcell\/koac104"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-08-16-0168-R"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/plcell\/koac041"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11091390"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e16474"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2021.2021992"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erac500"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.136668"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/plcell\/koac009"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinsphys.2010.11.006"},{"issue":"28","key":"e_1_2_7_43_1","article-title":"Virus\u2010Induced 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