{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:01:11Z","timestamp":1791468071186,"version":"4.3.4"},"reference-count":81,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["IOS\u20102414183"],"award-info":[{"award-number":["IOS\u20102414183"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["IOS\u20102110017"],"award-info":[{"award-number":["IOS\u20102110017"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["IOS\u20102343815"],"award-info":[{"award-number":["IOS\u20102343815"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Cell &amp; Environment"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In nature, plants are subjected to multiple environmental stress factors simultaneously or sequentially. Recent studies revealed that when three or more stress factors impact a plant simultaneously (termed \u2018multifactorial stress combination\u2019; MFSC), plant survival declines, even if the intensity of each individual stress involved in the MFSC is low. We previously identified RAP2.3 as a key transcription factor (TF) required for\n                    <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                    survival, specifically under a MFSC of salt+excess light+heat stress (i.e., S\u2009+\u2009EL\u2009+\u2009HS). Here we report that RAP2.3 regulates the expression of SIGMA3, a nuclear\u2010encoded factor that directs plastid RNA polymerase to specific plastid promoters, as well as MYB51, a key stress response TF involved in glucosinolate metabolism and oxidative stress responses, specifically during a MFSC of S\u2009+\u2009EL\u2009+\u2009HS. Like\n                    <jats:italic>rap2.3<\/jats:italic>\n                    mutants,\n                    <jats:italic>myb51<\/jats:italic>\n                    and\n                    <jats:italic>sig3<\/jats:italic>\n                    mutants display significantly low survival rate specifically under the MFSC of S\u2009+\u2009EL\u2009+\u2009HS. Based on MYB51 gene regulatory network analysis and characterisation of jasmonic acid (JA) mutants, we further reveal that suppression of JA signalling could play an important role in promoting plant survival under conditions of S\u2009+\u2009EL\u2009+\u2009HS. Our findings uncover an additional layer of the response of plants to MFSC, as well as identify potential targets for breeding crops with enhanced tolerance to climate change.\n                  <\/jats:p>","DOI":"10.1111\/pce.70963","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:23:08Z","timestamp":1791465788000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["RAP2.3 Is Required for\n                    <i>MYB51<\/i>\n                    and\n                    <i>SIGMA3<\/i>\n                    Expression During the Response of\n                    <i>Arabidopsis thaliana<\/i>\n                    to Multifactorial Stress Combination"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3372-6612","authenticated-orcid":false,"given":"Ranjita","family":"Sinha","sequence":"first","affiliation":[{"name":"Division of Plant Sciences and Technology, College of Agriculture Food and Natural Resources, Christopher S. Bond Life Sciences Center University of Missouri Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9739-9932","authenticated-orcid":false,"given":"Mar\u00eda \u00c1ngeles","family":"Pel\u00e1ez\u2010Vico","sequence":"additional","affiliation":[{"name":"Division of Plant Sciences and Technology, College of Agriculture Food and Natural Resources, Christopher S. Bond Life Sciences Center University of Missouri Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2614-6852","authenticated-orcid":false,"given":"Devasantosh","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Division of Plant Sciences and Technology, College of Agriculture Food and Natural Resources, Christopher S. Bond Life Sciences Center University of Missouri Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8634-8443","authenticated-orcid":false,"given":"Lidia S.","family":"Pascual","sequence":"additional","affiliation":[{"name":"Division of Plant Sciences and Technology, College of Agriculture Food and Natural Resources, Christopher S. Bond Life Sciences Center University of Missouri Columbia Missouri USA"},{"name":"Department of Biology, Biochemistry and Environmental Sciences University Jaume I. Av. de Vicent Sos Baynat Castell\u00f3 de la Plana Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1256-9371","authenticated-orcid":false,"given":"Sara I.","family":"Zandalinas","sequence":"additional","affiliation":[{"name":"Department of Biology, Biochemistry and Environmental Sciences University Jaume I. Av. de Vicent Sos Baynat Castell\u00f3 de la Plana Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Joan C. Edwards School of Medicine Marshall University Huntington West Virginia USA"},{"name":"Christopher S. Bond Life Science Center University of Missouri Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Bereimipour","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and BioDiscovery Institute, College of Science University of North Texas Denton North Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev K.","family":"Azad","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and BioDiscovery Institute, College of Science University of North Texas Denton North Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8944-4924","authenticated-orcid":false,"given":"Trupti","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Joan C. Edwards School of Medicine Marshall University Huntington West Virginia USA"},{"name":"Christopher S. Bond Life Science Center University of Missouri Columbia Missouri USA"},{"name":"Department of Electrical Engineering and Computer Science University of Missouri Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3192-7450","authenticated-orcid":false,"given":"Ron","family":"Mittler","sequence":"additional","affiliation":[{"name":"Division of Plant Sciences and Technology, College of Agriculture Food and Natural Resources, Christopher S. Bond Life Sciences Center University of Missouri Columbia Missouri USA"},{"name":"Advanced Agriculture Initiative Tel\u2010Hai University of Kiryat Shmona and the Galilee Kiryat Shmona Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/plphys\/kiaf006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.19.00956"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.16658"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2019.01775"},{"key":"e_1_2_9_6_1","first-page":"245","volume-title":"Purification of Proteins Using Polyhistidine Affinity Tags. In Methods in Enzymology","author":"Bornhorst J. A.","year":"2000"},{"key":"e_1_2_9_7_1","first-page":"15","volume-title":"Complex Environments Interact With Plant Development to Shape Glucosinolate Profiles. 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