{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:39:04Z","timestamp":1792568344794,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Cell &amp;amp; Environment"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Alternaria alternata<\/jats:italic>\n                    is a common pathogen responsible for leaf spots and postharvest decay in multiple crops, including sweet cherry. Coumarin, a plant\u2010derived compound, exhibits broad antifungal activity against plant pathogenic fungi including\n                    <jats:italic>A. alternata<\/jats:italic>\n                    . In this study, we found that coumarin significantly inhibited mycelial growth, conidiation, conidial germination, and infection of cherry tissues. Mechanistically, coumarin disrupted reactive oxygen species (ROS) homoeostasis, impaired membrane integrity, and inhibited ergosterol biosynthesis. Transcriptomic analysis revealed that coumarin dysregulated genes involved in membrane and sterol metabolism. Notably, coumarin activated the Hog1 (High osmolarity glycerol\u20101) dependent stress response pathway, as evidenced by nuclear accumulation of AaHog1 and increased coumarin sensitivity of \u2206\n                    <jats:italic>AaHog1<\/jats:italic>\n                    mutants. Furthermore, coumarin enhanced the efficacy of demethylation inhibitor (DMI) and dicarboximide (DCF) fungicides. Our findings demonstrate that coumarin acts through multiple antifungal mechanisms including HOG pathway activation, oxidative stress induction, and membrane disruption, highlighting its potential as a sustainable antifungal agent for controlling\n                    <jats:italic>A. alternata<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/pce.70995","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T06:45:51Z","timestamp":1792565151000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Coumarin Decouples ROS Homoeostasis, Membrane Integrity, and HOG Signalling to Inhibit\n                    <i>Alternaria alternata<\/i>"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8970-8763","authenticated-orcid":false,"given":"Rafakat","family":"Hussain","sequence":"first","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation Utilization of Horticultural Crops Huazhong Agricultural University Wuhan China"},{"name":"Hubei Key Laboratory of Plant Pathology Huazhong Agricultural University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8123-2553","authenticated-orcid":false,"given":"Zhe\u2010Zheng","family":"Zeng","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation Utilization of Horticultural Crops Huazhong Agricultural University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarti","family":"Aarti","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity &amp; Key Lab of Biopesticide and Chemical Biology, Ministry of Education, College of Plant Protection Fujian Agriculture and Forestry University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Zheng","family":"Cai","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation Utilization of Horticultural Crops Huazhong Agricultural University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5231-3979","authenticated-orcid":false,"given":"Wei\u2010Xiao","family":"Yin","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Plant Pathology Huazhong Agricultural University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9385-9898","authenticated-orcid":false,"given":"Chao\u2010Xi","family":"Luo","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation Utilization of Horticultural Crops Huazhong Agricultural University Wuhan China"},{"name":"Hubei Key Laboratory of Plant Pathology Huazhong Agricultural University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2020.10.013","article-title":"Coumarin Derivative, 5\u2032\u2010hydroxy\u2010auraptene, Extracted From Lotus lalambensis, Displays Antifungal and Anti\u2010Aflatoxigenic Activities Against Aspergillus flavus","volume":"33","author":"Ali E. 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