{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:30:37Z","timestamp":1791052237040,"version":"4.1.0"},"reference-count":218,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T00:00:00Z","timestamp":1353456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Metastatic cutaneous melanoma accounts for the majority of skin cancer deaths due to its aggressiveness and high resistance to current therapies. To efficiently metastasize, invasive melanoma cells need to change their cytoskeletal organization and alter contacts with the extracellular matrix and the surrounding stromal cells. Melanoma cells can use different migratory strategies depending on varying environments to exit the primary tumour mass and invade surrounding and later distant tissues. In this review, we have focused on tumour cell plasticity or the interconvertibility that melanoma cells have as one of the factors that contribute to melanoma metastasis. This has been an area of very intense research in the last 5\u00a0yr yielding a vast number of findings. We have therefore reviewed all the possible clinical opportunities that this new knowledge offers to both stratify and treat cutaneous malignant melanoma patients.<\/jats:p>","DOI":"10.1111\/pcmr.12041","type":"journal-article","created":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T22:57:02Z","timestamp":1351119422000},"page":"39-57","source":"Crossref","is-referenced-by-count":93,"title":["Emerging molecular targets in melanoma invasion and metastasis"],"prefix":"10.1111","volume":"26","author":[{"given":"Jose L.","family":"Orgaz","sequence":"first","affiliation":[{"name":"Randall Division of Cell and Molecular Biophysics King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Sanz\u2010Moreno","sequence":"additional","affiliation":[{"name":"Randall Division of Cell and Molecular Biophysics King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-2970"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.101444"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1996.tb01284.x"},{"key":"e_1_2_11_5_1","first-page":"4815","article-title":"Induction of growth factor RNA expression in human malignant melanoma: markers of transformation","volume":"51","author":"Albino A.P.","year":"1991","journal-title":"Cancer Res."},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63110-0"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3481"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.162"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.10.029"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200107107"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199711)173:2<275::AID-JCP35>3.0.CO;2-C"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2007.00433.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11071"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00144-09"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1185504"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0294-185"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/35020115"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2005.10.029"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00849.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201200041"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2271"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/35025220"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209582"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.406406"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.746"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200602085"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1145"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/22788"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1437206"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00049406"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(84)80310-X"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/35020106"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.10.030"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.5.9.3175"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2005.11.011"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.356"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3510095"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00766"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-1110fje"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1682"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880546"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.110635"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc745"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603291"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.03.024"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01148"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.0442"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.25"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng930"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1173569"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2505"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3218"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197111182852108"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2003.11.001"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2720"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200909003"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200701120"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2008.08.053"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M009449200"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2007.00378.x"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700524"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.09.022"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2005.10.022"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03664"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1973"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.7.2923-2931.2004"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-005-5865-1"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05661"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1880"},{"key":"e_1_2_11_70_1","first-page":"3056","article-title":"Targeted antiangiogenic therapy for cancer using Vitaxin: a humanized monoclonal antibody to the integrin alphavbeta3","volume":"6","author":"Gutheil J.C.","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:HIJO.0000032362.35354.bb"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5350.558"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_11_74_1","first-page":"2125","article-title":"Collective cell movement in primary melanoma explants: plasticity of cell\u2013cell interaction, beta1\u2010integrin function, and migration strategies","volume":"62","author":"Hegerfeldt Y.","year":"2002","journal-title":"Cancer Res."},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.12.040"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1092"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000096650.91688.28"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.024"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2007.00412.x"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2006.00322.x"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00068.x"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e328304974c"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.159715"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65730-6"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405102200"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.036525"},{"key":"e_1_2_11_87_1","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/S0026-895X(24)26508-1","article-title":"Pharmacological properties of Y\u201027632, a specific inhibitor of rho\u2010associated kinases","volume":"57","author":"Ishizaki T.","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209149"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803267"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.08.001"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.12.5565-5576.2004"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1144"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.17.7559-7566.2004"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0b013e31824ba4df"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.06.008"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0898-915"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.515"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-005-1580-1"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2359"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-005-1572-1"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200508000-00012"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1999.4497"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.1.423"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.11446"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1054603"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2009.05.003"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2006.07.008"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.07.008"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4233"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e318070d1bd"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1560"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.03.048"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1080\/1475636021000005659"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2004.00895.x"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2228"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.074849"},{"key":"e_1_2_11_117_1","first-page":"4174","article-title":"The 92\u2010kDa gelatinase B is expressed by advanced stage melanoma cells: suppression by somatic cell hybridization with early stage melanoma cells","volume":"55","author":"MacDougall J.R.","year":"1995","journal-title":"Cancer Res."},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2009.00585.x"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2007.09.009"},{"key":"e_1_2_11_120_1","doi-asserted-by":"crossref","first-page":"14270","DOI":"10.1016\/S0021-9258(18)77296-7","article-title":"Modulation of haptotactic migration of metastatic melanoma cells by the interaction between heparin and heparin\u2010binding domain of fibronectin","volume":"265","author":"Makabe T.","year":"1990","journal-title":"J. Biol. Chem."},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C400583200"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65173-5"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1998.85"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1834"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M513094200"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1995.1223"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052166"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-6787"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2616"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910520207"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5350.560"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205260"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4695(199812)37:4<487::AID-NEU1>3.0.CO;2-B"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1270"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.284"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1821"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc884"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2009.00618.x"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.05.034"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1845"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010901)92:5<1347::AID-CNCR1456>3.0.CO;2-0"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4280"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0766"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2729"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1675"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-0781"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1054"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1089\/108497801300189218"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209587"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10512"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092053"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65278-9"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80226-3"},{"key":"e_1_2_11_154_1","first-page":"4932","article-title":"Vascular endothelial growth factor, interleukin 8, platelet\u2010derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts","volume":"60","author":"Rofstad E.K.","year":"2000","journal-title":"Cancer Res."},{"key":"e_1_2_11_155_1","volume-title":"Rosai and Ackerman\u2032s Surgical Pathology","author":"Rosai J.","year":"2004"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.11.5.613"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5307.1790"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200807195"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2004.12.002"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc725"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1019"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200605135"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2010.08.020"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.09.043"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.06.018"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(02)00191-2"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006317125454"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2497"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.4065\/83.7.825"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04869"},{"key":"e_1_2_11_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(01)00009-0"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00144-3"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00044.2003"},{"key":"e_1_2_11_174_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.362"},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206454"},{"key":"e_1_2_11_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04304"},{"key":"e_1_2_11_177_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00023.2003"},{"key":"e_1_2_11_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206479"},{"key":"e_1_2_11_179_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1399"},{"key":"e_1_2_11_180_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703446104"},{"key":"e_1_2_11_181_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105358"},{"key":"e_1_2_11_182_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207812"},{"key":"e_1_2_11_183_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023772912750"},{"key":"e_1_2_11_184_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000113200"},{"key":"e_1_2_11_185_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E02-05-0291"},{"key":"e_1_2_11_186_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2005.00052.x"},{"key":"e_1_2_11_187_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01534"},{"key":"e_1_2_11_188_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2008.00506.x"},{"key":"e_1_2_11_189_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1448"},{"key":"e_1_2_11_190_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20116"},{"key":"e_1_2_11_191_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.191999.112"},{"key":"e_1_2_11_192_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2682"},{"key":"e_1_2_11_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.09.024"},{"key":"e_1_2_11_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90202-2"},{"key":"e_1_2_11_195_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902223"},{"key":"e_1_2_11_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.04.039"},{"key":"e_1_2_11_197_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.111102"},{"key":"e_1_2_11_198_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-2373"},{"key":"e_1_2_11_199_1","first-page":"1","volume-title":"Encyclopedia of Life Sciences (ELS)","author":"Villanueva J.","year":"2009"},{"key":"e_1_2_11_200_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050120"},{"key":"e_1_2_11_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00215-6"},{"key":"e_1_2_11_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00045-4"},{"key":"e_1_2_11_203_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200505059"},{"key":"e_1_2_11_204_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3433"},{"key":"e_1_2_11_205_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1443"},{"key":"e_1_2_11_206_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1230"},{"key":"e_1_2_11_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.03.015"},{"key":"e_1_2_11_208_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200209006"},{"key":"e_1_2_11_209_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.9.3192-3205.2001"},{"key":"e_1_2_11_210_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.3.301"},{"key":"e_1_2_11_211_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206451"},{"key":"e_1_2_11_212_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207383"},{"key":"e_1_2_11_213_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19980201)51:3<403::AID-JNR13>3.0.CO;2-7"},{"key":"e_1_2_11_214_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.2"},{"key":"e_1_2_11_215_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1366"},{"key":"e_1_2_11_216_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1275"},{"key":"e_1_2_11_217_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2734"},{"key":"e_1_2_11_218_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543780802565791"},{"key":"e_1_2_11_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2011.11.002"}],"container-title":["Pigment Cell &amp; Melanoma Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpcmr.12041","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.12041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T16:39:00Z","timestamp":1745080740000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcmr.12041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,21]]},"references-count":218,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/pcmr.12041"],"URL":"https:\/\/doi.org\/10.1111\/pcmr.12041","archive":["Portico"],"relation":{},"ISSN":["1755-1471","1755-148X"],"issn-type":[{"value":"1755-1471","type":"print"},{"value":"1755-148X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,21]]}}}