{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T20:49:29Z","timestamp":1773434969995,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T00:00:00Z","timestamp":1363305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Light exposure modulates development of living organisms. In the field of medicine, light has frequently been used for regenerative purposes. Excimer light (308\u00a0nm) has demonstrated superior efficacy in treating vitiligo, a condition requiring development of melanoblasts and a model for studying nerve cell regeneration, as compared to narrow\u2010band ultraviolet <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">NBUVB<\/jats:styled-content>; 311\u00a0nm). Using mouse\u2010derived melanoblast cells to examine the pro\u2010differentiation effects of these two light sources, we demonstrated that at equivalent fluence, excimer light induces melanoblast differentiation, while <jats:styled-content style=\"fixed-case\">NBUVB<\/jats:styled-content> failed to so. Mechanistically, activation of aryl hydrocarbon receptor pathway and nuclear translocation of epidermal growth factor receptor are involved in pro\u2010differentiation effects of excimer light. Reduction in irradiance by filter abrogated the effects of excimer light in melanoblasts, even when equivalent fluence was delivered by the same light source. As ultraviolet <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>) irradiation is closely associated pigment cell development, future therapy employing <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> for pigmentation purposes should incorporate irradiance as a crucial specification.<\/jats:p>","DOI":"10.1111\/pcmr.12077","type":"journal-article","created":{"date-parts":[[2013,2,12]],"date-time":"2013-02-12T09:10:46Z","timestamp":1360660246000},"page":"367-376","source":"Crossref","is-referenced-by-count":30,"title":["Irradiance, but not fluence, plays a crucial role in <scp>UVB<\/scp>\u2010induced immature pigment cell development: new insights for efficient <scp>UVB<\/scp> phototherapy"],"prefix":"10.1111","volume":"26","author":[{"given":"Cheng\u2010Che E.","family":"Lan","sequence":"first","affiliation":[{"name":"Department of Dermatology Kaohsiung Medical University Hospital Kaohsiung Taiwan"},{"name":"Department of Dermatology College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Dermatology Kaohsiung Municipal Ta\u2010Tung Hospital Kaoshiung Medical University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin\u2010Su","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kaohsiung Medical University Hospital Kaohsiung Taiwan"},{"name":"Department of Dermatology College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010He","family":"Lu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medical Science Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Shuang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science and Biotechnology Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiao\u2010Chi","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kaohsiung Medical University Hospital Kaohsiung Taiwan"},{"name":"Department of Dermatology College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02151.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12480997"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.018903"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09697.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701764104"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M706550200"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2005.20.2.273"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000743107"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1995.tb02372.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2004.00184.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.01.001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.269"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002040050600"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03311.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00818.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0901-802"},{"key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1016\/S0021-9258(19)81639-3","article-title":"Reduced formation of bipyrimidine photoproducts in DNA UV irradiated at high intensity","volume":"264","author":"Masnyk T.W.","year":"1989","journal-title":"J. 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