{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:44:48Z","timestamp":1791139488150,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T00:00:00Z","timestamp":1364169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Recent evidence indicates that oxidative stress and genetic factors play an important role in the pathogenesis of vitiligo. <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s involved in oxidative stress could potentially influence the development of vitiligo. In this case\u2013control study, we investigated the association of a functional <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> of rs11614913 in miR\u2010196a\u20102 with risk of vitiligo. A significantly lower risk of vitiligo was associated with the rs11614913 miR\u2010196a\u20102 <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> genotype (adjusted <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 0.77; <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.60\u20130.98). In addition, <jats:italic><jats:styled-content style=\"fixed-case\">TYRP<\/jats:styled-content>1<\/jats:italic> gene expression was considerably down\u2010regulated by the rs11614913 C allele in miR\u2010196a\u20102, which lowered the levels of intracellular reactive oxygen species (<jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>) and reduced the proportion of early apoptosis in human melanocytes in response to H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> treatment. Our data suggest that the rs11614913 C allele in miR\u2010196a\u20102 confers potential protection against oxidative effects on human melanocytes through the modulation of the target gene, <jats:italic><jats:styled-content style=\"fixed-case\">TYRP<\/jats:styled-content>1<\/jats:italic>, which may account for the decreased risk of vitiligo in this study population.<\/jats:p>","DOI":"10.1111\/pcmr.12081","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T21:03:11Z","timestamp":1361566991000},"page":"338-347","source":"Crossref","is-referenced-by-count":25,"title":["A single\u2010nucleotide polymorphism of miR\u2010196a\u20102 and vitiligo: an association study and functional analysis in a <scp>H<\/scp>an <scp>C<\/scp>hinese population"],"prefix":"10.1111","volume":"26","author":[{"given":"Ye","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Dermatology Xijing Hospital Fourth Military Medical University Xi'an China"},{"name":"Department of Dermatology General Hospital of Air Force Beijing China"},{"name":"Affiliated Hospital of Institute of Aviation Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuli","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology 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