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Transgenic mice spontaneously develop skin tumors with metastases in lymph nodes, lungs, liver, brain, and the bone marrow. Tumor lesions show typical melanoma morphology and express melanoma\u2010associated antigens. Although transgenic mice demonstrate an accumulation of melanoma antigen\u2010specific memory and effector <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells, their anti\u2010tumor effects could be blocked by highly immunosuppressive leukocytes enriched in the tumor microenvironment and in the periphery. Here, we discuss the role of one of the most potent immunosuppressive subset, regulatory <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells, in the melanoma progression in this model.<\/jats:p>","DOI":"10.1111\/pcmr.12104","type":"journal-article","created":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T10:14:39Z","timestamp":1365416079000},"page":"457-463","source":"Crossref","is-referenced-by-count":12,"title":["<i>Ret<\/i> transgenic mouse model of spontaneous skin melanoma: focus on regulatory <scp>T<\/scp> cells"],"prefix":"10.1111","volume":"26","author":[{"given":"Viktor","family":"Umansky","sequence":"first","affiliation":[{"name":"Skin Cancer Unit German Cancer Research Center Heidelberg Germany"},{"name":"Department of Dermatology, Venereology and Allergology University Medical Center Mannheim Ruprecht\u2010Karl University of Heidelberg Mannheim Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Sevko","sequence":"additional","affiliation":[{"name":"Skin Cancer Unit German Cancer Research Center Heidelberg Germany"},{"name":"Department of Dermatology, Venereology and Allergology University Medical Center Mannheim Ruprecht\u2010Karl University of Heidelberg Mannheim Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers4020490"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nrc2256","article-title":"Models, mechanisms and clinical evidence for cancer dormancy","volume":"11","author":"Aguirre\u2010Ghiso J.A.","year":"2007","journal-title":"Nat. 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