{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:38:12Z","timestamp":1785368292652,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T00:00:00Z","timestamp":1368403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We investigated the contributions of <jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>yrp1<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>pnmb<\/jats:italic> to the iris transillumination defect (<jats:styled-content style=\"fixed-case\">TID<\/jats:styled-content>) in five age cohorts of <jats:styled-content style=\"fixed-case\">BXD<\/jats:styled-content> mice. Using systems genetics, we also evaluated the role of other known pigmentation genes (<jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>s). Mapping studies indicate that <jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>yrp1<\/jats:italic> contributes to the phenotype at all ages, yet the <jats:styled-content style=\"fixed-case\">TID<\/jats:styled-content> maps to <jats:italic><jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>pnmb<\/jats:italic> only in the oldest cohort. Composite interval mapping reveals secondary loci viz. <jats:italic><jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>ca2<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>yo5a, <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>rkcz, and <jats:styled-content style=\"fixed-case\">Z<\/jats:styled-content>btb20<\/jats:italic> that modulate the phenotype in the age groups up to 10\u201313\u00a0months. The contributions of <jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>yrp1<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>pnmb<\/jats:italic> were highly significant in all age cohorts. Moreover, in young mice, all six gene candidates had substantial interactions in our model. Our model accounted for 71\u201388% of the explained variance of the <jats:styled-content style=\"fixed-case\">TID<\/jats:styled-content> phenotype across the age bins. These results demonstrate that along with <jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>yrp1<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>pnmb<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>ca2<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>yo5a, <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>rkcz, and <jats:styled-content style=\"fixed-case\">Z<\/jats:styled-content>btb20<\/jats:italic> modulate the <jats:styled-content style=\"fixed-case\">TID<\/jats:styled-content> in an age\u2010dependent manner.<\/jats:p>","DOI":"10.1111\/pcmr.12106","type":"journal-article","created":{"date-parts":[[2013,4,13]],"date-time":"2013-04-13T14:46:40Z","timestamp":1365864400000},"page":"487-498","source":"Crossref","is-referenced-by-count":16,"title":["Genetic modulation of the iris transillumination defect: a systems genetics analysis using the expanded family of <scp>BXD<\/scp> glaucoma strains"],"prefix":"10.1111","volume":"26","author":[{"given":"Shankar","family":"Swaminathan","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Hamilton Eye Institute, University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hamilton Eye Institute, University of Tennessee Health Science Center Memphis TN USA"},{"name":"The Affiliated Hospital of Nantong University Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology University of Tennessee Health Science Center Memphis TN USA"},{"name":"Jiangsu Key Laboratory of Neuroregeneration Nantong University Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica M.","family":"Jablonski","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hamilton Eye Institute, University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng794"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2008.00482.x"},{"key":"e_1_2_7_4_1","volume-title":"Pigmentary Glaucoma","author":"Ball S.F.","year":"2004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00067.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527636150"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-1464"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/7741"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20042070"},{"key":"e_1_2_7_10_1","volume-title":"Ocular Histology","author":"Fine B.S.","year":"1979"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/165.4.2071"},{"key":"e_1_2_7_12_1","first-page":"1730","article-title":"Gene expression in the mouse eye: an online resource for genetics using 103 strains of mice","volume":"15","author":"Geisert E.E.","year":"2009","journal-title":"Mol. 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