{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:31:22Z","timestamp":1790069482225,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T00:00:00Z","timestamp":1378166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    We have recently reported that human melanoma cells express a variety of voltage\u2010gated calcium (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ) channel types, including low\u2010voltage\u2010activated T\u2010type channels that play a significant role in melanoma cell cycle progression. Here, we challenged melanoma metastatic cells with T\u2010type channel blockers of clinical use and found a dual effect on cell viability: (i) a reduction in the proliferation rate, through a halt in the progression to the G\n                    <jats:sub>1<\/jats:sub>\n                    \u2010S phase; and (ii) a promotion of cell death that was partially dependent on the activation of caspases. An in\u2010depth analysis of the death process showed that the apoptotic pathway is preceded by endoplasmic reticulum stress and the subsequent inhibition of the basal macroautophagy which is active in these cells. The effects of pharmacological blockers on Ca\n                    <jats:sup>2+<\/jats:sup>\n                    homeostasis, autophagy, and cell death were mimicked by T\u2010type channel gene silencing. These results provide the basis for a new pharmacological and\/or gene silencing approach toward tackling melanoma metastasis.\n                  <\/jats:p>","DOI":"10.1111\/pcmr.12155","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T05:50:49Z","timestamp":1376286649000},"page":"874-885","source":"Crossref","is-referenced-by-count":63,"title":["T\u2010type calcium channel blockers inhibit autophagy and promote apoptosis of malignant melanoma cells"],"prefix":"10.1111","volume":"26","author":[{"given":"Arindam","family":"Das","sequence":"first","affiliation":[{"name":"UdL\u2010IRBLleida Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charumathi","family":"Pushparaj","sequence":"additional","affiliation":[{"name":"UdL\u2010IRBLleida Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Herreros","sequence":"additional","affiliation":[{"name":"UdL\u2010IRBLleida Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Nager","sequence":"additional","affiliation":[{"name":"UdL\u2010IRBLleida Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Vilella","sequence":"additional","affiliation":[{"name":"Servei d'Immunologia Hospital Cl\u00ednic de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Portero","sequence":"additional","affiliation":[{"name":"UdL\u2010IRBLleida Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinald","family":"Pamplona","sequence":"additional","affiliation":[{"name":"UdL\u2010IRBLleida Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Matias\u2010Guiu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Genetics Hospital Universitari Arnau de Vilanova UdL\u2010 IRBLleida Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa M.","family":"Mart\u00ed","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitari Arnau de Vilanova UdL\u2010IRBLleida Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Cant\u00ed","sequence":"additional","affiliation":[{"name":"UdL\u2010IRBLleida Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2634"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/595092"},{"key":"e_1_2_9_4_1","first-page":"1517","article-title":"The effects of mibefradil, a novel calcium channel antagonist on ventricular arrhythmias induced by myocardial ischemia and programmed electrical stimulation","volume":"277","author":"Billman G.E.","year":"1996","journal-title":"J. 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