{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:45:33Z","timestamp":1791499533304,"version":"4.3.4"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Spontaneously occurring melanomas are frequent in dogs. They appear at the same localizations as in humans, i.e. skin, mucosal sites, nail matrix and eyes. They display variable behaviors: tumors at oral localizations are more frequent and aggressive than at other anatomical sites. Interestingly, dog melanomas are associated with strong breed predispositions and overrepresentation of black\u2010coated dogs. Epidemiological analysis of 2350 affected dogs showed that poodles are at high risk of developing oral melanoma, while schnauzers or Beauce shepherds mostly developped cutaneous melanoma. Clinical and histopathological analyses were performed on a cohort of 153 cases with a 4\u2010yr follow\u2010up. Histopathological characterization showed that most canine tumors are intradermal and homologous to human rare morphological melanomas types \u2013 \u2018nevocytoid type\u2019 and \u2018animal type\u2019\u2010. Tumor\n                    <jats:styled-content style=\"fixed-case\">cDNA<\/jats:styled-content>\n                    sequencing data, obtained from 95 dogs for six genes, relevant to human melanoma classification, detected somatic mutations in oral melanoma, in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>NRAS<\/jats:italic>\n                    <\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>PTEN<\/jats:italic>\n                    <\/jats:styled-content>\n                    genes, at human hotspot sites, but not in\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content>\n                    <\/jats:italic>\n                    . Altogether, these findings support the relevance of the dog model for comparative oncology of melanomas, especially for the elucidation of non\u2010\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    induced pathways.\n                  <\/jats:p>","DOI":"10.1111\/pcmr.12170","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T18:05:57Z","timestamp":1381514757000},"page":"90-102","source":"Crossref","is-referenced-by-count":175,"title":["Naturally occurring melanomas in dogs as models for non\u2010\n                    <scp>UV<\/scp>\n                    pathways of human melanomas"],"prefix":"10.1111","volume":"27","author":[{"given":"Marc","family":"Gillard","sequence":"first","affiliation":[{"name":"CNRS UMR 6290 Institut G\u00e9n\u00e9tique et D\u00e9veloppement de Rennes Rennes France"},{"name":"Facult\u00e9 de M\u00e9decine SFR Biosit Universit\u00e9 Rennes 1 Rennes 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