{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:29:49Z","timestamp":1789507789001,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T00:00:00Z","timestamp":1384300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Non\u2010segmental vitiligo (<jats:styled-content style=\"fixed-case\">NSV<\/jats:styled-content>) is an enigmatic disease with various clinical courses. To empirically identify underlying subtypes of <jats:styled-content style=\"fixed-case\">NSV<\/jats:styled-content>, we performed latent class analysis (<jats:styled-content style=\"fixed-case\">LCA<\/jats:styled-content>) of 717 consecutive patients with <jats:styled-content style=\"fixed-case\">NSV<\/jats:styled-content> seen between 2006 and 2012 and were analyzed. Median age was 32\u00a0yrs (14\u201345), median age at <jats:styled-content style=\"fixed-case\">NSV<\/jats:styled-content> onset was 18\u00a0yrs (8\u201332), and median <jats:styled-content style=\"fixed-case\">NSV<\/jats:styled-content> duration 5\u00a0yrs (0.75\u201378.5). A two\u2010class model showed the best fit. Of the 717 patients, 280 (39%) belonged to <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>1 and 437 (61%) to <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>2. <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>1 patients had high probabilities for early disease onset (&lt;12\u00a0yrs), halo nevi, family history of premature hair greying, Koebner phenomenon, previous episodes of repigmentation, and family history of vitiligo. By contrast, <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>2 patients were characterized by a late disease onset (after or at the age of 12\u00a0yrs, median age of 30\u00a0yrs) and acrofacial localization without any lesions on trunk or limbs. These two <jats:styled-content style=\"fixed-case\">LCA<\/jats:styled-content> classes (<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>1, \u2018prepubertal onset\u2019; <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>2, \u2018post\u2010pubertal onset\u2019) may help refining results from genome\u2010wide association studies (<jats:styled-content style=\"fixed-case\">GWAS<\/jats:styled-content>) and allow a more accurate genotype\u2013phenotype correlation and help defining more directed treatment protocols.<\/jats:p>","DOI":"10.1111\/pcmr.12186","type":"journal-article","created":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T07:01:03Z","timestamp":1381906863000},"page":"134-139","source":"Crossref","is-referenced-by-count":36,"title":["Latent class analysis of a series of 717 patients with vitiligo allows the identification of two clinical subtypes"],"prefix":"10.1111","volume":"27","author":[{"given":"Khaled","family":"Ezzedine","sequence":"first","affiliation":[{"name":"Department of Dermatology and Pediatric Dermatology National Centre for Rare Skin Disorders H\u00f4pital Pellegrin and University of Bordeaux and Inserm U1035 Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Le Thuaut","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Est Cr\u00e9teil (UPEC) LIC EA4393 Creteil France"},{"name":"Department of Public Health h\u00f4pital Henri\u2010Mondor Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Cr\u00e9teil France"},{"name":"Unit\u00e9 de Recherche Clinique Mondor (URC) Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Jouary","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Pediatric 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