{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:03:38Z","timestamp":1762542218613},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T00:00:00Z","timestamp":1386720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2014,3]]},"abstract":"Summary<\/jats:title>An association between low serum vitamin D<\/jats:styled-content> levels and poorer melanoma survival has been reported. We have studied inheritance of a polymorphism of the GC<\/jats:styled-content><\/jats:italic> gene, rs2282679, coding for the vitamin D<\/jats:styled-content>\u2010binding protein, which is associated with lower serum levels of vitamin D<\/jats:styled-content>, in a meta\u2010analysis of 3137 melanoma patients. The aim was to investigate evidence for a causal relationship between vitamin D<\/jats:styled-content> and outcome (M<\/jats:styled-content>endelian randomization). The variant was not associated with reduced overall survival (OS)<\/jats:styled-content> in the UK<\/jats:styled-content> cohort, per\u2010allele hazard ratio (HR<\/jats:styled-content>) for death 1.23 (95% confidence interval (CI)<\/jats:styled-content> 0.93, 1.64). In the smaller cohorts, HR<\/jats:styled-content> in OS<\/jats:styled-content> analysis was 1.07 (95% CI<\/jats:styled-content> 0.88, 1.3) and for all cohorts combined, HR<\/jats:styled-content> for OS<\/jats:styled-content> was 1.09 (95% CI<\/jats:styled-content> 0.93, 1.29). There was evidence of increased melanoma\u2010specific deaths in the seven cohorts for which these data were available. The lack of unequivocal findings despite the large sample size illustrates the difficulties of implementing M<\/jats:styled-content>endelian randomization.<\/jats:p>","DOI":"10.1111\/pcmr.12193","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T07:33:43Z","timestamp":1384328023000},"page":"234-243","source":"Crossref","is-referenced-by-count":26,"title":["An inherited variant in the gene coding for vitamin D<\/scp>\u2010binding protein and survival from cutaneous melanoma: a B<\/scp>ioG<\/scp>enoMEL<\/scp> study"],"prefix":"10.1111","volume":"27","author":[{"given":"John R.","family":"Davies","sequence":"first","affiliation":[{"name":"Section of Epidemiology and Biostatistics Leeds Institute of Cancer and Pathology University of Leeds Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinead","family":"Field","sequence":"additional","affiliation":[{"name":"Section of Epidemiology and Biostatistics Leeds Institute of Cancer and Pathology University of Leeds Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliette","family":"Randerson\u2010Moor","sequence":"additional","affiliation":[{"name":"Section of Epidemiology and Biostatistics Leeds Institute of Cancer and Pathology University of Leeds Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Harland","sequence":"additional","affiliation":[{"name":"Section of Epidemiology and Biostatistics Leeds Institute of Cancer and Pathology University of Leeds Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajiv","family":"Kumar","sequence":"additional","affiliation":[{"name":"Genetic Epidemiology German Cancer Research Center Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella M.","family":"Anic","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology H. Lee Moffitt Cancer Center & Research Institute Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Nagore","sequence":"additional","affiliation":[{"name":"Department of Dermatology Instituto Valenciano de Oncolog\u00eda c\/Profesor Beltr\u00e1n B\u00e1guena Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Hansson","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet Karolinska University Hospital Solna Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"H\u00f6iom","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet Karolinska University Hospital Solna Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"J\u00f6nsson","sequence":"additional","affiliation":[{"name":"Departments of Oncology and Cancer Epidemiology Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelleke A.","family":"Gruis","sequence":"additional","affiliation":[{"name":"Melanoma research group Leids Universitair Mediasch Centrum Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Y.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology H. Lee Moffitt Cancer Center & Research Institute Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Guan","sequence":"additional","affiliation":[{"name":"Genetic Epidemiology German Cancer Research Center Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Sivaramakrishna Rachakonda","sequence":"additional","affiliation":[{"name":"Genetic Epidemiology German Cancer Research Center Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Wendt","sequence":"additional","affiliation":[{"name":"Department of Dermatology Division of General Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dace","family":"Pjanova","sequence":"additional","affiliation":[{"name":"Latvian Biomedical Research and Study Center Riga Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Puig","sequence":"additional","affiliation":[{"name":"Melanoma Unit Department of Dermatology Hospital Cl\u00ednic de Barcelona IDIBAPS Barcelona University Barcelona Spain"},{"name":"Centre of Biomedical Research on Rare Diseases (CIBERER) ISCIII Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Schadendorf","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Essen Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Division of General Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e5kan","family":"Olsson","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet Karolinska University Hospital Solna Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Affleck","sequence":"additional","affiliation":[{"name":"Section of Epidemiology and Biostatistics Leeds Institute of Cancer and Pathology University of Leeds Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaida","family":"Garc\u00eda\u2010Casado","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology Instituto Valenciano de Oncolog\u00eda c\/Profesor Beltr\u00e1n B\u00e1guena Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan Anton","family":"Puig\u2010Butille","sequence":"additional","affiliation":[{"name":"Melanoma Unit Department of Dermatology Hospital Cl\u00ednic de Barcelona IDIBAPS Barcelona University Barcelona Spain"},{"name":"Centre of Biomedical Research on Rare Diseases (CIBERER) ISCIII Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander J.","family":"Stratigos","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Athens School of Medicine Andreas Sygros Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Kodela","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Athens School of Medicine Andreas Sygros Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Donina","sequence":"additional","affiliation":[{"name":"Latvian Biomedical Research and Study Center Riga Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antje","family":"Sucker","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Essen Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Hosen","sequence":"additional","affiliation":[{"name":"Genetic Epidemiology German Cancer Research Center Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen M.","family":"Egan","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology H. 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