{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:47:24Z","timestamp":1791946044528,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T00:00:00Z","timestamp":1389571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Inducible\n                    <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>\n                    70 (\n                    <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>\n                    70i) chaperones peptides from stressed cells, protecting them from apoptosis. Upon extracellular release,\n                    <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>\n                    70i serves an adjuvant function, enhancing immune responses to bound peptides. We questioned whether\n                    <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>\n                    70i differentially protects control and vitiligo melanocytes from stress and subsequent immune responses. We compared expression of\n                    <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>\n                    70i in skin samples, evaluated the viability of primary vitiligo and control melanocytes exposed to bleaching phenols, and measured secreted\n                    <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>\n                    70i. We determined whether\n                    <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>\n                    70i traffics to melanosomes to contact immunogenic proteins by cell fractionation, western blotting, electron microscopy, and confocal microscopy. Viability of vitiligo and control melanocytes was equally affected under stress. However, vitiligo melanocytes secreted increased amounts of\n                    <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>\n                    70i in response to\n                    <jats:styled-content style=\"fixed-case\">MBEH<\/jats:styled-content>\n                    , corroborating with aberrant\n                    <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>\n                    70i expression in patient skin. Intracellular\n                    <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>\n                    70i colocalized with melanosomes, and more so in response to\n                    <jats:styled-content style=\"fixed-case\">MBEH<\/jats:styled-content>\n                    in vitiligo melanocytes. Thus, whereas either agent is cytotoxic to melanocytes,\n                    <jats:styled-content style=\"fixed-case\">MBEH<\/jats:styled-content>\n                    preferentially induces immune responses to melanocytes.\n                  <\/jats:p>","DOI":"10.1111\/pcmr.12208","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T01:34:56Z","timestamp":1387503296000},"page":"209-220","source":"Crossref","is-referenced-by-count":83,"title":["Preferential secretion of inducible\n                    <scp>HSP<\/scp>\n                    70 by vitiligo melanocytes under stress"],"prefix":"10.1111","volume":"27","author":[{"given":"Jeffrey A.","family":"Mosenson","sequence":"first","affiliation":[{"name":"Departments of Pathology and Microbiology &amp; Immunology\/Cardinal Bernardin Cancer Center Loyola University Chicago Maywood IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey","family":"Flood","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Microbiology &amp; Immunology\/Cardinal Bernardin Cancer Center Loyola University Chicago Maywood IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Klarquist","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Microbiology &amp; Immunology\/Cardinal Bernardin Cancer Center Loyola University Chicago Maywood IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Eby","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Microbiology &amp; Immunology\/Cardinal Bernardin Cancer Center Loyola University Chicago Maywood IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Koshoffer","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Cincinnati Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond E.","family":"Boissy","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Cincinnati Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Overbeck","sequence":"additional","affiliation":[{"name":"Lumiderm Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca C.","family":"Tung","sequence":"additional","affiliation":[{"name":"Department of Medicine Loyola University Chicago Maywood IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. Caroline","family":"Le Poole","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Microbiology &amp; Immunology\/Cardinal Bernardin Cancer Center Loyola University Chicago Maywood IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2012.11.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.13.2491"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.413"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-007-0057-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(00)01874-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2004.00130.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12480976"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.2006.01706.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.16"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-8-19"},{"key":"e_1_2_7_12_1","first-page":"222","article-title":"Human heat shock protein 70 peptide complexes specifically activate antimelanoma T cells","volume":"61","author":"Castelli C.","year":"2001","journal-title":"Cancer Res."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/JDN.0b013e3181fe9b33"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr060363j"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(92)90147-Y"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.45"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2006.02.008"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e328343f542"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708007200"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2272"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161213804143644"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.1.108"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.04.024"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23653.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.90942"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M502017200"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1993.1102"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12476645"},{"key":"e_1_2_7_29_1","doi-asserted-by":"crossref","first-page":"7284","DOI":"10.4049\/jimmunol.151.12.7284","article-title":"A novel, antigen\u2010presenting function of melanocytes and its possible relationship to hypopigmentary disorders","volume":"151","author":"Poole I.C.","year":"1993","journal-title":"J. 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