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X\u2010ray repair cross\u2010complementary protein 1, <jats:styled-content style=\"fixed-case\">XRCC<\/jats:styled-content>1, plays a critically important role in base excision repair pathway. This study was therefore performed to analyze the correlation between <jats:styled-content style=\"fixed-case\">XRCC<\/jats:styled-content>1 expression, melanoma progression, and patient survival. Using a tissue microarray with a total of 119 patients with melanoma, we demonstrate that loss of <jats:styled-content style=\"fixed-case\">XRCC<\/jats:styled-content>1 expression is associated with the progression of disease from dysplastic nevi to primary melanoma and to metastatic melanoma. We found that the loss of <jats:styled-content style=\"fixed-case\">XRCC<\/jats:styled-content>1 was correlated with the progression of melanoma from <jats:styled-content style=\"fixed-case\">AJCC<\/jats:styled-content> stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> to stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> and with worse overall and disease\u2010specific 5\u2010yr and 10\u2010yr survival of patients with melanoma. Furthermore, we also illustrate the inhibitory effect of <jats:styled-content style=\"fixed-case\">XRCC<\/jats:styled-content>1 on melanoma cell invasion and migration, which are the regulatory events in melanoma metastasis.<\/jats:p>","DOI":"10.1111\/pcmr.12212","type":"journal-article","created":{"date-parts":[[2014,1,11]],"date-time":"2014-01-11T18:55:07Z","timestamp":1389466507000},"page":"366-375","source":"Crossref","is-referenced-by-count":12,"title":["Loss of <scp>XRCC<\/scp>1 confers a metastatic phenotype to melanoma cells and is associated with poor survival in patients with melanoma"],"prefix":"10.1111","volume":"27","author":[{"given":"Madhuri","family":"Bhandaru","sequence":"first","affiliation":[{"name":"Department of Dermatology and Skin Science University of British Columbia Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Martinka","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of British Columbia Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Skin Science University of British Columbia Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand","family":"Rotte","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Skin Science University of British Columbia Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27980"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1569-y"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.4799"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064851"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki543"},{"key":"e_1_2_7_7_1","first-page":"423","article-title":"Cell migration and actin organization in cultured human primary, recurrent cutaneous and metastatic melanoma. 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