{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:25:49Z","timestamp":1789835149843,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T00:00:00Z","timestamp":1391040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A rare germline variant in the microphthalmia\u2010associated transcription factor (<jats:italic><jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>)<\/jats:italic>gene, E318K, has been reported as associated with melanoma. We confirmed its independent association with melanoma [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 1.7, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>)\u00a0=\u00a01.1, 2.7, P<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.03]; adjusted for age, sex, center, age\u00a0\u00d7\u00a0sex interaction, pigmentation characteristics, family history of melanoma, and nevus density). In stratified analyses, carriage of<jats:italic><jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content><\/jats:italic>E318K was associated with melanoma more strongly in people with dark hair than fair hair (P for interaction, 0.03) and in those with no moles than some or many moles (P for interaction, &lt;0.01). There was no evidence of interaction between<jats:italic><jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>1R<\/jats:italic>\u2018red hair variants\u2019 and<jats:italic><jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content><\/jats:italic>E318K. Moreover, risk of melanoma among carriers with \u2018low risk\u2019 phenotypes was as great or greater than among those with \u2018at risk\u2019 phenotypes with few exceptions.<\/jats:p>","DOI":"10.1111\/pcmr.12215","type":"journal-article","created":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T01:23:57Z","timestamp":1389317037000},"page":"485-488","source":"Crossref","is-referenced-by-count":34,"title":["<i><scp>MITF<\/scp><\/i>E318K's effect on melanoma risk independent of, but modified by, other risk factors"],"prefix":"10.1111","volume":"27","author":[{"given":"Marianne","family":"Berwick","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine and Dermatology University of New Mexico Albuquerque NM USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"MacArthur","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and Dermatology University of New Mexico Albuquerque NM 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Mexico Albuquerque NM USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Reiner","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan\u2010Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan\u2010Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce K.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"School of Public Health University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Kricker","sequence":"additional","affiliation":[{"name":"School of Public Health University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne 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