{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:12:35Z","timestamp":1790993555282,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T00:00:00Z","timestamp":1392940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Immune\u2010mediated responses are consistently observed in progressing vitiligo at the edge of depigmenting patches. Besides the role of the adaptive immune system, the profile of the innate immune response is now at the center of the stage. We report that plasmacytoid dendritic cells (<jats:styled-content style=\"fixed-case\">pDC<\/jats:styled-content>), which are the major interferon (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>)\u2010alpha\u2010producing cells, are part of the infiltrate of progressive vitiligo with local production of MxA (a protein induced by <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content><jats:italic>\u03b1<\/jats:italic>). MxA was associated with expression of the type I <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010inducible ligand <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>9 and correlated with the recruitment of <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>3<jats:sup>+<\/jats:sup> immune cells. Interestingly, strong MxA expression was observed in perilesional skin in close apposition to remaining melanocytes, surrounded by a prominent T\u2010cell infiltrate. In contrast, MxA was not detectable in lesional skin, suggesting that <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic> production is an early event in the progression of the disease. Our data highlight a new innate immune pathway leading to progression of vitiligo.<\/jats:p>","DOI":"10.1111\/pcmr.12219","type":"journal-article","created":{"date-parts":[[2014,1,18]],"date-time":"2014-01-18T14:26:43Z","timestamp":1390055203000},"page":"398-407","source":"Crossref","is-referenced-by-count":156,"title":["Type <scp>I<\/scp> interferon signature in the initiation of the immune response in vitiligo"],"prefix":"10.1111","volume":"27","author":[{"given":"Antoine","family":"Bertolotti","sequence":"first","affiliation":[{"name":"Department of Dermatology and Pediatric Dermatology National Centre for Rare Skin Disorders Saint\u2010Andr\u00e9 and Pellegrin Hospital Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Boniface","sequence":"additional","affiliation":[{"name":"INSERM U1035 Immunodermatology Team Universit\u00e9 Bordeaux Segalen Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Vergier","sequence":"additional","affiliation":[{"name":"Department of Pathology Haut\u2010L\u00e9v\u00e8que Hospitals Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djavad","family":"Mossalayi","sequence":"additional","affiliation":[{"name":"INSERM U1035 Immunodermatology Team Universit\u00e9 Bordeaux Segalen Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Taieb","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Pediatric Dermatology National Centre for Rare Skin Disorders Saint\u2010Andr\u00e9 and Pellegrin Hospital Bordeaux France"},{"name":"INSERM U1035 Immunodermatology Team Universit\u00e9 Bordeaux Segalen Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Ezzedine","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Pediatric Dermatology National Centre for Rare Skin Disorders Saint\u2010Andr\u00e9 and Pellegrin Hospital Bordeaux France"},{"name":"INSERM U1035 Immunodermatology Team Universit\u00e9 Bordeaux Segalen Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Seneschal","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Pediatric Dermatology National Centre for Rare Skin Disorders Saint\u2010Andr\u00e9 and Pellegrin Hospital Bordeaux France"},{"name":"INSERM U1035 Immunodermatology Team Universit\u00e9 Bordeaux Segalen Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00032.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.02719.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2006.0107"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12034"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2004.00130.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2009.01.004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2006.00333.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2012.0171"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2012.00997.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/43.1.7822763"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61689-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.463"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061592"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908547"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.273"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.12"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2012.24.4.482"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05152.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000131485"},{"key":"e_1_2_7_21_1","first-page":"1219","article-title":"Presence of T cells and macrophages in inflammatory vitiligo skin parallels melanocyte disappearance","volume":"148","author":"Le Poole I.C.","year":"1996","journal-title":"Am. J. Pathol."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1222808110"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00290"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037513"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01899.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.251"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12183"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005127"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050500"},{"key":"e_1_2_7_30_1","first-page":"558","article-title":"Plasmacytoid dendritic cells: one\u2010trick ponies or workhorses of the immune system?","volume":"11","author":"Reizis B.","year":"2011","journal-title":"Nat. Rev."},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.02.004"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00666.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09329.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354607"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00319"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/skinbio.2011.7"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01533.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.13.s8.9.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2007.00393.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00939.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2006.00355.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0804388"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2010.01587.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2010.00703.x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11158.x"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00556.x"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.96"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1309\/4EJ9KL7CGDENVVLE"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2005.00297.x"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00527.x"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0194"}],"container-title":["Pigment Cell &amp; Melanoma Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpcmr.12219","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.12219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:20:50Z","timestamp":1695558050000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcmr.12219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,21]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/pcmr.12219"],"URL":"https:\/\/doi.org\/10.1111\/pcmr.12219","archive":["Portico"],"relation":{},"ISSN":["1755-1471","1755-148X"],"issn-type":[{"value":"1755-1471","type":"print"},{"value":"1755-148X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,21]]}}}