{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T01:27:03Z","timestamp":1778981223937,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T00:00:00Z","timestamp":1396828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004361","name":"Krebsliga Schweiz","doi-asserted-by":"crossref","award":["OCS-02272-08-2008"],"award-info":[{"award-number":["OCS-02272-08-2008"]}],"id":[{"id":"10.13039\/501100004361","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The ciliary body and iris are pigmented epithelial structures in the anterior eye segment that function to maintain correct intra\u2010ocular pressure and regulate exposure of the internal eye structures to light, respectively. The cellular and molecular factors that mediate the development of the ciliary body and iris from the ocular pigmented epithelium remain to be fully elucidated. Here, we have investigated the role of Notch signaling during the development of the anterior pigmented epithelium by using genetic loss\u2010 and gain\u2010of\u2010function approaches. Loss of canonical Notch signaling results in normal iris development but absence of the ciliary body. This causes progressive hypotony and over time leads to phthisis bulbi, a condition characterized by shrinkage of the eye and loss of structure\/function. Conversely, Notch gain\u2010of\u2010function results in aniridia and profound ciliary body hyperplasia, which causes ocular hypertension and glaucoma\u2010like disease. Collectively, these data indicate that Notch signaling promotes ciliary body development at the expense of iris formation and reveals novel animal models of human ocular pathologies.<\/jats:p>","DOI":"10.1111\/pcmr.12236","type":"journal-article","created":{"date-parts":[[2014,3,15]],"date-time":"2014-03-15T14:26:35Z","timestamp":1394893595000},"page":"580-589","source":"Crossref","is-referenced-by-count":5,"title":["Notch signaling in the pigmented epithelium of the anterior eye segment promotes ciliary body development at the expense of iris formation"],"prefix":"10.1111","volume":"27","author":[{"given":"Bhushan","family":"Sarode","sequence":"first","affiliation":[{"name":"School of Life Science Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL) Lausanne Switzerland"},{"name":"Swiss Institute for Experimental Cancer Research (ISREC) Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig S.","family":"Nowell","sequence":"additional","affiliation":[{"name":"School of Life Science Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL) Lausanne Switzerland"},{"name":"Swiss Institute for Experimental Cancer Research (ISREC) Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JongEun","family":"Ihm","sequence":"additional","affiliation":[{"name":"School of Life Science Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL) Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinne","family":"Kostic","sequence":"additional","affiliation":[{"name":"Unit of Gene Therapy and Stem Cell Biology Jules\u2010Gonin Eye Hospital University of Lausanne Lausanne Switzerland"},{"name":"Eye Pathology Laboratory Jules\u2010Gonin Eye Hospital University of Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvan","family":"Arsenijevic","sequence":"additional","affiliation":[{"name":"Unit of Gene Therapy and Stem Cell Biology Jules\u2010Gonin Eye Hospital University of Lausanne Lausanne Switzerland"},{"name":"Eye Pathology Laboratory Jules\u2010Gonin Eye Hospital University of Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre P.","family":"Moulin","sequence":"additional","affiliation":[{"name":"Eye Pathology Laboratory Jules\u2010Gonin Eye Hospital University of Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel F.","family":"Schorderet","sequence":"additional","affiliation":[{"name":"School of Life Science Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL) Lausanne Switzerland"},{"name":"Eye Pathology Laboratory Jules\u2010Gonin Eye Hospital University of Lausanne Lausanne Switzerland"},{"name":"IRO \u2013 Institute for Research in Ophthalmology Sion Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich","family":"Beermann","sequence":"additional","affiliation":[{"name":"School of Life Science Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL) Lausanne Switzerland"},{"name":"Swiss Institute for Experimental Cancer Research (ISREC) Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freddy","family":"Radtke","sequence":"additional","affiliation":[{"name":"School of Life Science Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL) Lausanne Switzerland"},{"name":"Swiss Institute for Experimental Cancer Research (ISREC) Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.11.046"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.120"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20725"},{"issue":"2","key":"e_1_2_7_5_1","first-page":"123","article-title":"Development of the ciliary body: a brief review","volume":"105","author":"Beebe D.C.","year":"1986","journal-title":"Trans. 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