{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:51:12Z","timestamp":1777438272774,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,4,11]],"date-time":"2014-04-11T00:00:00Z","timestamp":1397174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fondazione San Paolo","award":["2011.1172"],"award-info":[{"award-number":["2011.1172"]}]},{"name":"Italian Association for Cancer Research (AIRC)","award":["12035"],"award-info":[{"award-number":["12035"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Little is known as to how cells ensure that organelle size and number are coordinated to correctly couple organelle biogenesis to the demands of proliferation or differentiation. <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>1 is a melanosome\u2010associated <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>\u2010protein\u2010coupled receptor involved in melanosome biogenesis during melanocyte differentiation. Cells lacking <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>1 contain fewer, but larger, mature melanosomes. Here, we show that <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>1 loss of function reduces both the basal expression and the \u03b1\u2010melanocyte\u2010stimulating hormone\/c<jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content>\u2010dependent induction of the microphthalmia\u2010associated transcription factor (<jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>), the master regulator of melanocyte differentiation. In turn, this leads to a significant reduction in expression of <jats:styled-content style=\"fixed-case\">PMEL<\/jats:styled-content>, a major melanosomal structural protein, but does not affect tyrosinase and melanin levels. In line with its pivotal role in sensing melanosome maturation, <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>1 expression rescues melanosome biogenesis, activates <jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content> expression and thereby coordinates melanosome size and number, providing a quality control mechanism for the organelle in which resides. Thus, resident sensor receptors can activate a transcriptional cascade to specifically promote organelle biogenesis.<\/jats:p>","DOI":"10.1111\/pcmr.12239","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T19:01:34Z","timestamp":1395342094000},"page":"565-579","source":"Crossref","is-referenced-by-count":24,"title":["Melanosome\u2010autonomous regulation of size and number: the <scp>OA<\/scp>1 receptor sustains <scp>PMEL<\/scp> expression"],"prefix":"10.1111","volume":"27","author":[{"given":"Paola","family":"Falletta","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine University of Genoa Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Bagnato","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine University of Genoa Genoa 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