{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:11:01Z","timestamp":1790431861294,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,6,30]],"date-time":"2014-06-30T00:00:00Z","timestamp":1404086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C107\/A10433"],"award-info":[{"award-number":["C107\/A10433"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["A13540"],"award-info":[{"award-number":["A13540"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C5759\/A12328"],"award-info":[{"award-number":["C5759\/A12328"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005976","name":"Harry J. Lloyd Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005976","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Acral melanoma is a subtype of melanoma with distinct epidemiological, clinical and mutational profiles. To define the genomic alterations in acral melanoma, we conducted whole\u2010genome sequencing and <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> array analysis of five metastatic tumours and their matched normal genomes. We identified the somatic mutations, copy number alterations and structural variants in these tumours and combined our data with published studies to identify recurrently mutated genes likely to be the drivers of acral melanomagenesis. We compared and contrasted the genomic landscapes of acral, mucosal, uveal and common cutaneous melanoma to reveal the distinctive mutational characteristics of each subtype.<\/jats:p>","DOI":"10.1111\/pcmr.12279","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T09:43:52Z","timestamp":1402393432000},"page":"835-838","source":"Crossref","is-referenced-by-count":126,"title":["The mutational burden of acral melanoma revealed by whole\u2010genome sequencing and comparative analysis"],"prefix":"10.1111","volume":"27","author":[{"given":"Simon J.","family":"Furney","sequence":"first","affiliation":[{"name":"Molecular Oncology Group Cancer Research UK Manchester Institute Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samra","family":"Turajlic","sequence":"additional","affiliation":[{"name":"Signal Transduction Team Division of Cancer Biology Institute of Cancer Research London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Stamp","sequence":"additional","affiliation":[{"name":"Experimental Pathology Laboratory Cancer Research UK London Research Institute London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Meirion","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Surgery Royal Marsden Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hayes","sequence":"additional","affiliation":[{"name":"Department of Surgery Royal Marsden Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Strauss","sequence":"additional","affiliation":[{"name":"Department of Surgery Royal Marsden Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Gavrielides","sequence":"additional","affiliation":[{"name":"Molecular Oncology Group Cancer Research UK Manchester Institute Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xing","sequence":"additional","affiliation":[{"name":"Scientific Computing Cancer Research UK Manchester Institute Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Gore","sequence":"additional","affiliation":[{"name":"Melanoma Unit Royal Marsden Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Larkin","sequence":"additional","affiliation":[{"name":"Melanoma Unit Royal Marsden Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Marais","sequence":"additional","affiliation":[{"name":"Molecular Oncology Group Cancer Research UK Manchester Institute Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,30]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12477"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11071"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1301689"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2762"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050092"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.2984"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11143"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp995"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2012.01016.x"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-13-0330"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4204"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2012.10.002"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.024"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2359"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12323"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2004.06.057"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08031.x"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.125591.111"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu049"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.07.013"}],"container-title":["Pigment Cell &amp; Melanoma Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpcmr.12279","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.12279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:55:13Z","timestamp":1695570913000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcmr.12279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,30]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/pcmr.12279"],"URL":"https:\/\/doi.org\/10.1111\/pcmr.12279","archive":["Portico"],"relation":{},"ISSN":["1755-1471","1755-148X"],"issn-type":[{"value":"1755-1471","type":"print"},{"value":"1755-148X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,30]]}}}