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In resulting Vitesse mice, spontaneous skin depigmentation precedes symmetrical and sharply demarcated patches of graying hair. Whereas the <jats:styled-content style=\"fixed-case\">SCF<\/jats:styled-content> transgene alone dictates a greater retinoic acid receptor\u2010related orphan receptor gamma (<jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content>\u03b3t)<jats:sup>+<\/jats:sup> T\u2010cell compartment, these cells displayed markedly increased <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 expression within Vitesse mice. Similar to patient skin, regulatory T cells were less abundant compared with <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>14\u2010<jats:styled-content style=\"fixed-case\">SCF<\/jats:styled-content> mice, with the exception of gradually appearing patches of repigmenting skin. The subtle repigmentation observed likely reflects resilient melanocytes that coexist with skin\u2010infiltrating, melanocyte\u2010reactive T cells. Similar repigmenting lesions were found in a different <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content> transgenic model of vitiligo developed on an <jats:styled-content style=\"fixed-case\">SCF<\/jats:styled-content> transgenic background, supporting a role for <jats:styled-content style=\"fixed-case\">SCF<\/jats:styled-content> in repigmentation.<\/jats:p>","DOI":"10.1111\/pcmr.12284","type":"journal-article","created":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T13:33:28Z","timestamp":1403012008000},"page":"1075-1085","source":"Crossref","is-referenced-by-count":38,"title":["Immune responses in a mouse model of vitiligo with spontaneous epidermal de\u2010 and repigmentation"],"prefix":"10.1111","volume":"27","author":[{"given":"Jonathan M.","family":"Eby","sequence":"first","affiliation":[{"name":"Oncology Research Institute Loyola University Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee\u2010Kap","family":"Kang","sequence":"additional","affiliation":[{"name":"Oncology Research Institute Loyola University Chicago Chicago IL USA"},{"name":"Department of Surgery Loyola University Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Klarquist","sequence":"additional","affiliation":[{"name":"Oncology Research Institute Loyola University Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpak","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical University of South Carolina Charleston SC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Mosenson","sequence":"additional","affiliation":[{"name":"Oncology Research Institute Loyola University Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael I.","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Oncology Research Institute Loyola University Chicago Chicago IL USA"},{"name":"Department of Surgery Loyola University Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Garrett\u2010Mayer","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology Medical University of South Carolina Charleston SC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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