{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T18:43:33Z","timestamp":1768070613122,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T00:00:00Z","timestamp":1407110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Patients with melanoma may develop skin depigmentation spontaneously or following therapy, referred to as melanoma\u2010associated leucoderma (<jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content>). As clinical presentation of <jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content> may precede primary\/metastatic melanoma detection, recognition of <jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content> is important to prevent its misdiagnosis as vitiligo and the subsequent application of immunosuppressive treatment. To reveal the immunity involved in <jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content> development, we investigated the presence of antibody and T\u2010cell immune responses directed against the melanocyte\u2010differentiation\u2010antigens <jats:styled-content style=\"fixed-case\">MART<\/jats:styled-content>\u20101 (Melan\u2010A), tyrosinase and gp100 in patients with <jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content>, as compared to patients with vitiligo. Autoantibodies to gp100 and tyrosinase were commonly found in both diseases. Interestingly, <jats:styled-content style=\"fixed-case\">MART<\/jats:styled-content>\u20101 antibodies were only present in patients with <jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content>. Melanocyte antigen\u2010specific T cells were found in all patients, with relatively more specific T cells in patients with active vitiligo. Although <jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content> and vitiligo may appear clinically similar, our results indicate that the humoral immune responses against <jats:styled-content style=\"fixed-case\">MART<\/jats:styled-content>\u20101 differ between these diseases, which can help to differentiate <jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content> from vitiligo.<\/jats:p>","DOI":"10.1111\/pcmr.12294","type":"journal-article","created":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T08:20:48Z","timestamp":1405585248000},"page":"1086-1096","source":"Crossref","is-referenced-by-count":26,"title":["The antibody response against <scp>MART<\/scp>\u20101 differs in patients with melanoma\u2010associated leucoderma and vitiligo"],"prefix":"10.1111","volume":"27","author":[{"given":"Hansje\u2010Eva","family":"Teulings","sequence":"first","affiliation":[{"name":"Department of Dermatology Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin J.","family":"Willemsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Glykofridis","sequence":"additional","affiliation":[{"name":"Department of Dermatology Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle","family":"Krebbers","sequence":"additional","affiliation":[{"name":"Department of Dermatology Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Komen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marije W.","family":"Kroon","sequence":"additional","affiliation":[{"name":"Department of Dermatology Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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