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We examined global miRNA expression profiles in fresh\u2010frozen metastatic melanomas in relation to clinical outcome and <jats:italic>BRAF<\/jats:italic> mutation, with validation in independent cohorts of tumours and sera. We integrated miRNA and mRNA information from the same samples and elucidated networks associated with outcome and mutation. Associations with prognosis were replicated for miR\u2010150\u20105p, miR\u2010142\u20103p and miR\u2010142\u20105p. Co\u2010analysis of miRNA and mRNA uncovered a network associated with poor prognosis (<jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>) that paradoxically favoured expression of miRNAs opposing tumorigenesis. These miRNAs are likely part of an autoregulatory response to oncogenic drivers, rather than drivers themselves. Robust association of miR\u2010150\u20105p and the miR\u2010142 duplex with good prognosis and earlier stage metastatic melanoma supports their potential as biomarkers. miRNAs overexpressed in association with <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content> in an autoregulatory fashion will not be suitable therapeutic targets.<\/jats:p>","DOI":"10.1111\/pcmr.12343","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T18:10:43Z","timestamp":1418148643000},"page":"254-266","source":"Crossref","is-referenced-by-count":64,"title":["MicroRNA and mRNA expression profiling in metastatic melanoma reveal associations with <i>BRAF<\/i> mutation and patient prognosis"],"prefix":"10.1111","volume":"28","author":[{"given":"Varsha","family":"Tembe","sequence":"first","affiliation":[{"name":"Westmead Millennium Institute The University of Sydney Sydney NSW Australia"},{"name":"Melanoma Institute Australia The University of Sydney, Sydney NSW 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