{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:48:03Z","timestamp":1788871683393,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T00:00:00Z","timestamp":1423785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"The Danish Council for Independent Research (The Sapere Aude programme)"},{"name":"Aarhus University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    We show that the multiligand receptor megalin, known to mediate uptake and trafficking of nutrients and signaling molecules, is frequently expressed in malignant melanoma samples. Expression of megalin\u2010encoding\n                    <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                    was investigated in 65 samples of nevi, melanomas, and melanoma metastases and was observed in more than 60% of the malignant samples, while only in 20% of the benign counterparts. Megalin expression in nevus and melanoma samples was additionally investigated by immunohistochemistry, which confirmed our\n                    <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                    \u2010based observations. We furthermore show that a panel of tumor\u2010derived melanoma cell lines express\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">LRP<\/jats:styled-content>\n                      2\n                    <\/jats:italic>\n                    \/megalin endogenously. In these cells, megalin is internalized from the cell surface and localizes extensively to intracellular vesicles, confirming receptor activity and pointing toward association with the endocytic apparatus. Groundbreaking, our results indicate that sustained megalin expression in melanoma cells is crucial for cell maintenance, as si\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    \u2010mediated reduction in melanoma cell expression of\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">LRP<\/jats:styled-content>\n                      2\n                    <\/jats:italic>\n                    \/megalin significantly decreases melanoma cell proliferation and survival rates.\n                  <\/jats:p>","DOI":"10.1111\/pcmr.12352","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T14:07:49Z","timestamp":1421244469000},"page":"267-280","source":"Crossref","is-referenced-by-count":35,"title":["Melanoma tumors frequently acquire\n                    <i>\n                      <scp>LRP<\/scp>\n                      2\n                    <\/i>\n                    \/megalin expression, which modulates melanoma cell proliferation and survival rates"],"prefix":"10.1111","volume":"28","author":[{"given":"Rikke K.","family":"Andersen","sequence":"first","affiliation":[{"name":"Department of Biomedicine University of Aarhus Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine","family":"Hammer","sequence":"additional","affiliation":[{"name":"Department of Biomedicine University of Aarhus Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Hager","sequence":"additional","affiliation":[{"name":"Department of Pathology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie N.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine University of Aarhus Aarhus 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