{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:47:32Z","timestamp":1791946052713,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T00:00:00Z","timestamp":1423785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Vitiligo Research Foundation"},{"name":"Shahani Foundation"},{"name":"Henry Ford Health System Research","award":["T71016"],"award-info":[{"award-number":["T71016"]}]},{"name":"Henry Ford Health System Research","award":["T71017"],"award-info":[{"award-number":["T71017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Although non\u2010segmental vitiligo (\n                    <jats:styled-content style=\"fixed-case\">NSV<\/jats:styled-content>\n                    ) results from the autoimmune destruction of melanocytes, the detailed immune mechanisms have not yet been fully elucidated. Th17 cells have been identified to be implicated in human autoimmune diseases. In this study, the frequencies of peripheral blood Th17 cells and serum levels of\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201017A and Th17 cell\u2010related cytokines were examined in 45 patients with active\n                    <jats:styled-content style=\"fixed-case\">NSV<\/jats:styled-content>\n                    compared to 45 race\u2010, gender\u2010, and age\u2010matched healthy controls. Our results showed increased circulating Th17 cell frequencies and elevated serum\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201017A,\n                    <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\n                    \u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1, and\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201021 levels in patients with\n                    <jats:styled-content style=\"fixed-case\">NSV<\/jats:styled-content>\n                    . Meanwhile, the increased Th17 cell frequencies are positively correlated with serum\n                    <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\n                    \u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1 level, and the body surface area of lesions is positively correlated with elevated\n                    <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\n                    \u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1 and\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201021 levels and Th17 cell frequencies. Furthermore, positive correlation was identified between Th17 and Th1 cell frequencies in patients with\n                    <jats:styled-content style=\"fixed-case\">NSV<\/jats:styled-content>\n                    . These results further indicate the potential involvement of Th17 cells and the collaborative contribution of Th17 and Th1 in\n                    <jats:styled-content style=\"fixed-case\">NSV<\/jats:styled-content>\n                    development, and suggest that the elevated serum\n                    <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\n                    \u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1 and\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201021 levels could contribute to enhanced Th17 cell differentiation in\n                    <jats:styled-content style=\"fixed-case\">NSV<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/pcmr.12355","type":"journal-article","created":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T09:47:09Z","timestamp":1421833629000},"page":"324-329","source":"Crossref","is-referenced-by-count":78,"title":["Increased circulating Th17 cells and elevated serum levels of\n                    <scp>TGF<\/scp>\n                    \u2010beta and\n                    <scp>IL<\/scp>\n                    \u201021 are correlated with human non\u2010segmental vitiligo development"],"prefix":"10.1111","volume":"28","author":[{"given":"Li","family":"Zhou","sequence":"first","affiliation":[{"name":"Henry Ford Immunology Program Henry Ford Health System Detroit MI USA"},{"name":"Department of Dermatology Vitiligo Treatment and Research Center Henry Ford Health System Detroit MI USA"},{"name":"Department of Internal Medicine Henry Ford Health System Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ling","family":"Shi","sequence":"additional","affiliation":[{"name":"Henry Ford Immunology Program Henry Ford Health System Detroit MI USA"},{"name":"Department of Dermatology Vitiligo Treatment and Research Center Henry Ford Health System Detroit MI USA"},{"name":"Department of Dermatology Shanghai Tenth Peoples Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[{"name":"Henry Ford Immunology Program Henry Ford Health System Detroit MI USA"},{"name":"Department of Dermatology Vitiligo Treatment and Research Center Henry Ford Health System Detroit MI USA"},{"name":"Department of Dermatology Xijing Hospital Fourth Military Medical University Xian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iltefat","family":"Hamzavi","sequence":"additional","affiliation":[{"name":"Henry Ford Immunology Program Henry Ford Health System Detroit MI USA"},{"name":"Department of Dermatology Vitiligo Treatment and Research Center Henry Ford Health System Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian\u2010Wen","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xijing Hospital Fourth Military Medical University Xian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H.","family":"Huggins","sequence":"additional","affiliation":[{"name":"Department of Dermatology Vitiligo Treatment and Research Center Henry Ford Health System Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry W.","family":"Lim","sequence":"additional","affiliation":[{"name":"Henry Ford Immunology Program Henry Ford Health System Detroit MI USA"},{"name":"Department of Dermatology Vitiligo Treatment and Research Center Henry Ford Health System Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010Sheng","family":"Mi","sequence":"additional","affiliation":[{"name":"Henry Ford Immunology Program Henry Ford Health System Detroit MI USA"},{"name":"Department of Dermatology Vitiligo Treatment and Research Center Henry Ford Health System Detroit MI USA"},{"name":"Department of Internal Medicine Henry Ford Health System Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03972.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00920.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04753"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1995"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.540"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.12.008"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1684\/ejd.2013.2023","article-title":"Interleukin 17, Interleukin 22 and FoxP3 expression in tissue and serum of non\u2010segmental vitiligo: a case\u2013controlled study on eighty\u2010four patients","volume":"23","author":"Elela M.A.","year":"2013","journal-title":"Eur. J. Dermatol."},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07802.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.463"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908547"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.602"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2272"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.07.018"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-133967"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00945.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.7.4733"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002949"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-05-089375"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061308"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701213"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.03.044"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.07.001"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809317106"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-120998"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030896"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05969"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00023.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.603"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.5.3137"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007811"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.377"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.92668"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.321"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.05.005"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-011-1154-8"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.32"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.01.001"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1613"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018907"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000069521.42488.1B"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07021"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05505"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2012.01019.x"}],"container-title":["Pigment Cell &amp; Melanoma Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpcmr.12355","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpcmr.12355","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.12355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:02:31Z","timestamp":1695560551000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcmr.12355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,13]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/pcmr.12355"],"URL":"https:\/\/doi.org\/10.1111\/pcmr.12355","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725321532.793522582","asserted-by":"object"}]},"ISSN":["1755-1471","1755-148X"],"issn-type":[{"value":"1755-1471","type":"print"},{"value":"1755-148X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,13]]}}}