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The\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>\n                    <\/jats:italic>\n                    gene is amplified in ~20% of melanomas and\n                    <jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>\n                    mutation can predispose to melanoma development. Furthermore, the regulation of\n                    <jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>\n                    expression and function is strongly linked to the\n                    <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">MEK<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">ERK<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>\n                    \u2010kinase (\n                    <jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content>\n                    ) pathway, which is deregulated in &gt;90% of melanomas and central target of current therapies.\n                    <jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>\n                    expression in melanoma is heterogeneous, and recent findings highlight the relevance of this heterogeneity for the response of melanoma to\n                    <jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content>\n                    pathway targeting drugs, as well as for\n                    <jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>\n                    's role in melanoma progression. This review aims to provide an updated overview on the regulation of\n                    <jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>\n                    function and plasticity in melanoma with a focus on its link to\n                    <jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content>\n                    signaling.\n                  <\/jats:p>","DOI":"10.1111\/pcmr.12370","type":"journal-article","created":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T22:02:25Z","timestamp":1427407345000},"page":"390-406","source":"Crossref","is-referenced-by-count":225,"title":["Microphthalmia\u2010associated transcription factor in melanoma development and\n                    <scp>MAP<\/scp>\n                    \u2010kinase pathway targeted therapy"],"prefix":"10.1111","volume":"28","author":[{"given":"Claudia","family":"Wellbrock","sequence":"first","affiliation":[{"name":"Manchester Cancer Research Centre Wellcome Trust Centre for Cell Matrix Research Faculty of Life Sciences The University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imanol","family":"Arozarena","sequence":"additional","affiliation":[{"name":"Manchester Cancer Research Centre Wellcome Trust Centre for Cell Matrix Research Faculty of Life Sciences The University of Manchester Manchester 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