{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:36Z","timestamp":1772160876401,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T00:00:00Z","timestamp":1430870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 CA121974"],"award-info":[{"award-number":["P50 CA121974"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content>\n                    inhibitors have revolutionized treatment of mutant\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content>\n                    <\/jats:italic>\n                    metastatic melanomas. However, resistance develops rapidly following\n                    <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content>\n                    inhibitor treatment. We have found that\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content>\n                    <\/jats:italic>\n                    \u2010mutant melanoma cell lines are more sensitive than wild\u2010type\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content>\n                    <\/jats:italic>\n                    cells to the small molecule tyrosine kinase inhibitor dovitinib. Sensitivity is associated with inhibition of a series of known dovitinib targets. Dovitinib in combination with several agents inhibits growth more effectively than either agent alone. These combinations inhibit\n                    <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content>\n                    \u2010mutant melanoma and colorectal carcinoma cell lines, including cell lines with intrinsic or selected\n                    <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content>\n                    inhibitor resistance. Hence, combinations of dovitinib with second agents are potentially effective therapies for\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content>\n                    <\/jats:italic>\n                    \u2010mutant melanomas, regardless of their sensitivity to\n                    <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content>\n                    inhibitors.\n                  <\/jats:p>","DOI":"10.1111\/pcmr.12376","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T03:54:48Z","timestamp":1428551688000},"page":"417-430","source":"Crossref","is-referenced-by-count":11,"title":["The broad\u2010spectrum receptor tyrosine kinase inhibitor dovitinib suppresses growth of\n                    <i>\n                      <scp>BRAF<\/scp>\n                    <\/i>\n                    \u2010mutant melanoma cells in combination with other signaling pathway inhibitors"],"prefix":"10.1111","volume":"28","author":[{"given":"Casey G.","family":"Langdon","sequence":"first","affiliation":[{"name":"Department of Pathology Yale University School of Medicine New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew A.","family":"Held","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James T.","family":"Platt","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine New Haven CT USA"},{"name":"Breast Medical Oncology Group Yale University School of Medicine New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrina","family":"Meeth","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinar","family":"Iyidogan","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramanaiah","family":"Mamillapalli","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew B.","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongzhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus W.","family":"Bosenberg","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine New Haven CT USA"},{"name":"Department of Dermatology Yale University School of Medicine New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David F.","family":"Stern","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI65780"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-13-0481"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028973"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1989.tb08543.x"},{"key":"e_1_2_7_6_1","first-page":"2303","article-title":"Inhibition of the fibroblast growth factor receptor 1 (FGFR\u20101) gene in human melanocytes and malignant melanomas leads to inhibition of proliferation and signs indicative of differentiation","volume":"7","author":"Becker D.","year":"1992","journal-title":"Oncogene"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1337088100"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.11.013"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.10.031"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103782"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-11-0341"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1990"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00836.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60802-8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-3006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2612"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1210093"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0386"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02623492"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0408"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.594"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-1747"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12264"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-13-83"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.10.009"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6694"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.177"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.10.013"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70030-0"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6712"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09626"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203066"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20785"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10868"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M113.037424"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-12-0461"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1878"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-1466"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI67816"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-0140"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0022"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003643"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11183"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13121"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-13-45"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-3913"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-10-0512"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-13-0631"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0897-887"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11249"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.377218"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12089"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-13-0646"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2010.00823.x"}],"container-title":["Pigment Cell &amp; Melanoma Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpcmr.12376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpcmr.12376","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.12376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:55:57Z","timestamp":1695495357000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcmr.12376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,6]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/pcmr.12376"],"URL":"https:\/\/doi.org\/10.1111\/pcmr.12376","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725429112.793508078","asserted-by":"object"}]},"ISSN":["1755-1471","1755-148X"],"issn-type":[{"value":"1755-1471","type":"print"},{"value":"1755-148X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,6]]}}}