{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:16:12Z","timestamp":1791216972496,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,10,17]],"date-time":"2015-10-17T00:00:00Z","timestamp":1445040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hiege Stiftung gegen Hautkrebs"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The multifunctional <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g\u2010like carcinoembryonic antigen\u2010related cell adhesion molecule 1 (<jats:styled-content style=\"fixed-case\">CEACAM<\/jats:styled-content>1) is neo\u2010expressed in the majority of malignant melanoma lesions. <jats:styled-content style=\"fixed-case\">CEACAM<\/jats:styled-content>1 acts as a driver of tumor cell invasion, and its expression correlates with poor patient prognosis. Despite its importance in melanoma progression, how <jats:italic><jats:styled-content style=\"fixed-case\">CEACAM<\/jats:styled-content>1<\/jats:italic> expression is regulated is largely unknown. Here, we show that <jats:italic><jats:styled-content style=\"fixed-case\">CEACAM<\/jats:styled-content>1<\/jats:italic> expression in melanoma cell lines and melanoma tissue strongly correlates with that of the microphthalmia\u2010associated transcription factor (<jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>), a key regulator of melanoma proliferation and invasiveness. <jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content> is revealed as a direct and positive regulator for <jats:italic><jats:styled-content style=\"fixed-case\">CEACAM<\/jats:styled-content>1<\/jats:italic> expression via binding to an <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\u2010box motif located in the <jats:italic><jats:styled-content style=\"fixed-case\">CEACAM<\/jats:styled-content>1<\/jats:italic> promoter. Taken together, our study provides novel insights into the regulation of <jats:italic><jats:styled-content style=\"fixed-case\">CEACAM<\/jats:styled-content>1<\/jats:italic> expression and suggests an <jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CEACAM<\/jats:styled-content>1 axis as a potential determinant of melanoma progression.<\/jats:p>","DOI":"10.1111\/pcmr.12414","type":"journal-article","created":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T15:33:27Z","timestamp":1440430407000},"page":"736-740","source":"Crossref","is-referenced-by-count":13,"title":["<scp>MITF<\/scp> is a critical regulator of the carcinoembryonic antigen\u2010related cell adhesion molecule 1 (<scp>CEACAM<\/scp>1) in malignant melanoma"],"prefix":"10.1111","volume":"28","author":[{"given":"Nico","family":"Ullrich","sequence":"first","affiliation":[{"name":"Skin Cancer Unit of the Dermatology Department Medical Faculty West German Cancer Center University Duisburg\u2010Essen Essen Germany"},{"name":"German Cancer Consortium (DKTK) Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"L\u00f6ffek","sequence":"additional","affiliation":[{"name":"Skin Cancer Unit of the Dermatology Department Medical Faculty West German Cancer Center University Duisburg\u2010Essen Essen Germany"},{"name":"German Cancer Consortium (DKTK) Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Horn","sequence":"additional","affiliation":[{"name":"Skin Cancer Unit of the Dermatology Department Medical Faculty West German Cancer Center University Duisburg\u2010Essen Essen Germany"},{"name":"German Cancer Consortium (DKTK) Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Ennen","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire Illkirch\u2010Graffenstaden France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"S\u00e1nchez\u2010del\u2010Campo","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Medicine Ludwig Institute for Cancer Research University of Oxford Headington Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Skin Cancer Unit of the Dermatology Department Medical Faculty West German Cancer Center University Duisburg\u2010Essen Essen Germany"},{"name":"German Cancer Consortium (DKTK) Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Breitenbuecher","sequence":"additional","affiliation":[{"name":"German Cancer Consortium (DKTK) Essen Germany"},{"name":"Department of Medical Oncology West German Cancer Center Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irwin","family":"Davidson","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire Illkirch\u2010Graffenstaden France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard B.","family":"Singer","sequence":"additional","affiliation":[{"name":"Institute of Anatomy University Hospital University Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Schadendorf","sequence":"additional","affiliation":[{"name":"Skin Cancer Unit of the Dermatology Department Medical Faculty West German Cancer Center University Duisburg\u2010Essen Essen Germany"},{"name":"German Cancer Consortium (DKTK) Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin R.","family":"Goding","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Medicine Ludwig Institute for Cancer Research University of Oxford Headington Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Helfrich","sequence":"additional","affiliation":[{"name":"Skin Cancer Unit of the Dermatology Department Medical Faculty West German Cancer Center University Duisburg\u2010Essen Essen Germany"},{"name":"German Cancer Consortium (DKTK) Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,17]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012513-104658"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20102575"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.44"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63433-5"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60802-8"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2008.00505.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00893.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.12.8.3653"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cgt.7700055"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-009-0740-5"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.22.10744"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-11-0526"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215549704500705"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.05.033"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-1752"}],"container-title":["Pigment Cell &amp; Melanoma Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpcmr.12414","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.12414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:11:20Z","timestamp":1695571880000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcmr.12414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,17]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/pcmr.12414"],"URL":"https:\/\/doi.org\/10.1111\/pcmr.12414","archive":["Portico"],"relation":{},"ISSN":["1755-1471","1755-148X"],"issn-type":[{"value":"1755-1471","type":"print"},{"value":"1755-148X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,17]]}}}