{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:39:49Z","timestamp":1791272389136,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,17]],"date-time":"2016-01-17T00:00:00Z","timestamp":1452988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005190","name":"Melanoma Research Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001215","name":"La Trobe University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001215","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content><\/jats:italic> mutations at codons L597 and K601 occur uncommonly in melanoma. Clinical and pathological associations of these mutations were investigated in a cohort of 1119 patients with known <jats:italic><jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content><\/jats:italic> mutation status. A <jats:italic><jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content><\/jats:italic> mutation was identified in 435 patients; Mutations at L597 and the K601E mutation were seen in 3.4 and 3.2% of these, respectively. K601E melanomas tended to occur in male patients, a median age of 58\u00a0yr, were generally found on the trunk (64%) and uncommonly associated with chronically sun\u2010damaged (<jats:styled-content style=\"fixed-case\">CSD<\/jats:styled-content>) skin. <jats:italic><jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content><\/jats:italic> L597 melanomas occurred in older patients (median 66\u00a0yr), but were associated with <jats:styled-content style=\"fixed-case\">CSD<\/jats:styled-content> skin (extremities or head and neck location \u2013 73.3%, P\u00a0=\u00a00.001). Twenty\u2010three percent of patients with V600E\u2010 and 43% of patients with K601E\u2010mutant melanomas presented with nodal disease at diagnosis compared to just 14% of patients with <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content> wild\u2010type tumors (P\u00a0=\u00a00.001 and 0.006, respectively). Overall, these mutations represent a significant minority of <jats:italic><jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content><\/jats:italic> mutations, but have distinct clinicopathological phenotypes and clinical behaviors.<\/jats:p>","DOI":"10.1111\/pcmr.12450","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T03:13:27Z","timestamp":1449630807000},"page":"222-228","source":"Crossref","is-referenced-by-count":17,"title":["Clinicopathological characteristics associated with <scp>BRAF<\/scp><sup>K601E<\/sup> and <scp>BRAF<\/scp><sup>L597<\/sup> mutations in melanoma"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4242-1300","authenticated-orcid":false,"given":"Mark","family":"Voskoboynik","sequence":"first","affiliation":[{"name":"Peter MacCallum Cancer Centre East Melbourne Vic. Australia"},{"name":"Victorian Melanoma Service Alfred Hospital Prahran Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Mar","sequence":"additional","affiliation":[{"name":"Victorian Melanoma Service Alfred Hospital Prahran Melbourne Vic. Australia"},{"name":"Skin and Cancer Foundation Melbourne Vic. Australia"},{"name":"Department of Epidemiology and Preventive Medicine Monash University Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Mailer","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre East Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Colebatch","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre East Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Fennessy","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre East Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Logan","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre East Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsee","family":"Hewitt","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre East Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon","family":"Cebon","sequence":"additional","affiliation":[{"name":"School of Cancer Medicine La Trobe University Olivia Newton\u2010John Cancer Research Institute Heidelberg Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kelly","sequence":"additional","affiliation":[{"name":"Victorian Melanoma Service Alfred Hospital Prahran Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"McArthur","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre East Melbourne Vic. Australia"},{"name":"Melbourne University Parkville Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,17]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Cancer in Australia: An Overview 2014","author":"AIHW","year":"2014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000099"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103782"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050092"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0097"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00766"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1210093"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203421"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60868-X"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.024"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2359"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408868"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.4327"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1406037"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg123"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-0398"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12295"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0052"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep01659"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20138"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1406498"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.044"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00215-6"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.11.806"}],"container-title":["Pigment Cell &amp; Melanoma Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpcmr.12450","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.12450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:21:51Z","timestamp":1695471711000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcmr.12450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,17]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/pcmr.12450"],"URL":"https:\/\/doi.org\/10.1111\/pcmr.12450","archive":["Portico"],"relation":{},"ISSN":["1755-1471","1755-148X"],"issn-type":[{"value":"1755-1471","type":"print"},{"value":"1755-148X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,17]]}}}