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During the last 5\u00a0yr, next\u2010generation sequencing (<jats:styled-content style=\"fixed-case\">NGS<\/jats:styled-content>) has enabled even more comprehensive mutational screening at the level of multigene panels, exomes and genomes. These studies have uncovered many new and unexpected players in melanoma development. The recent landmark study from The Cancer Genome Atlas (<jats:styled-content style=\"fixed-case\">TCGA<\/jats:styled-content>) consortium describing the genomic architecture of 333 cutaneous melanomas provides the largest and broadest analysis to date on the somatic aberrations underlying melanoma genesis. It thus seems timely to review the mutational landscape of melanoma and highlight the key genes and cellular pathways that appear to drive this cancer.<\/jats:p>","DOI":"10.1111\/pcmr.12459","type":"journal-article","created":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T08:55:13Z","timestamp":1454316913000},"page":"266-283","source":"Crossref","is-referenced-by-count":167,"title":["The genomic landscape of cutaneous melanoma"],"prefix":"10.1111","volume":"29","author":[{"given":"Tongwu","family":"Zhang","sequence":"first","affiliation":[{"name":"Laboratory of Translational Genomics Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Dutton\u2010Regester","sequence":"additional","affiliation":[{"name":"Cancer Program Broad Institute of Harvard and MIT Cambridge MA USA"},{"name":"Department of Medical Oncology Dana Farber Cancer Institute Boston MA 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