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We have examined how forced expression of the <jats:styled-content style=\"fixed-case\">NAD<\/jats:styled-content>(P)H quinone dehydrogenase, quinone 1 (<jats:styled-content style=\"fixed-case\">NQO<\/jats:styled-content>1), a major quinone\u2010reducing enzyme in cytosol, affects the survival of <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>\u2010treated cells. We found that treatment of the mouse melanoma cell line B16<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>6 or normal human melanocytes with carnosic acid, a transcriptional inducer of the <jats:italic><jats:styled-content style=\"fixed-case\">NQO<\/jats:styled-content>1<\/jats:italic> gene, notably suppressed the cell killing effect of <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>. This effect was mostly abolished by <jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content>936, a highly specific <jats:styled-content style=\"fixed-case\">NQO<\/jats:styled-content>1 inhibitor. Moreover, conditional overexpression of the human <jats:italic><jats:styled-content style=\"fixed-case\">NQO<\/jats:styled-content>1<\/jats:italic> transgene in B16<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>6 led to an expression\u2010dependent increase of cell survival after <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content> treatment. Our results suggest that <jats:styled-content style=\"fixed-case\">NQO<\/jats:styled-content>1 attenuates the cytotoxicity of <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content> and\/or its metabolites.<\/jats:p>","DOI":"10.1111\/pcmr.12461","type":"journal-article","created":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T04:11:53Z","timestamp":1454645513000},"page":"309-316","source":"Crossref","is-referenced-by-count":19,"title":["<scp>NAD<\/scp>(P)H dehydrogenase, quinone 1 (<scp>NQO<\/scp>1), protects melanin\u2010producing cells from cytotoxicity of rhododendrol"],"prefix":"10.1111","volume":"29","author":[{"given":"Ayaka","family":"Okubo","sequence":"first","affiliation":[{"name":"Department of Tumor Biology Institute of Biomedical Sciences Iwate Medical University Shiwa\u2010gun Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Yasuhira","sequence":"additional","affiliation":[{"name":"Department of Tumor Biology Institute of Biomedical Sciences Iwate Medical University Shiwa\u2010gun Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Shibazaki","sequence":"additional","affiliation":[{"name":"Department of Tumor Biology Institute of Biomedical Sciences Iwate Medical University Shiwa\u2010gun Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Iwate Medical University Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihide","family":"Akasaka","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Iwate Medical University Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Iwate Medical University Shiwa\u2010gun Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihaya","family":"Maesawa","sequence":"additional","affiliation":[{"name":"Department of Tumor Biology Institute of Biomedical Sciences Iwate Medical University Shiwa\u2010gun Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.29.1970"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01977728"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.3.1188"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.319905"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms10062440"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.155"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11632"},{"key":"e_1_2_7_9_1","first-page":"255","article-title":"Chemical leukoderma: what's new on etiopathological and clinical aspects? 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