{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:04:54Z","timestamp":1789506294900,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T00:00:00Z","timestamp":1461196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The 4977\u2010base pair common deletion Dmt<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>4977 is the most frequently observed mitochondrial <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> mutation in human tissues. Because mitochondrial <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> mutations are mainly caused by reactive oxygen species (<jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>), and given that oxidative stress plays an important role in melanoma carcinogenesis, the investigation of Dmt<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>4977 may be particularly relevant to the development of melanoma. In this study, we compared Dmt<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>4977 levels in blood leukocytes from 206 melanoma patients and 219 healthy controls. Overall, melanoma cases had significantly higher levels of Dmt<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>4977 than healthy controls (median: 0.60 vs 0.20, P\u00a0=\u00a00.008). The difference was evident among individuals who were older than 47\u00a0yrs, women, and had pigmentation risk factors (e.g., blond or red hair, blue eye, fair skin, light, or none tanning ability after prolonged sun exposure, and freckling in the sun as a child). The difference was also evident among those who had at least one lifetime sunburn with blistering and had no reported use of a sunlamp. Interestingly, among controls, Dmt<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>4977 levels differed by phenotypic index and reported use of a sunlamp. In the risk assessment, increased levels of Dmt<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>4977 were associated with a 1.23\u2010fold increased risk of melanoma (odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>): 1.23, 95% confidence interval (90% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 1.01, 1.50). A significant dose\u2013response relationship was observed in quartile analysis (P\u00a0=\u00a00.001). In summary, our study suggests that high levels of Dmt<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>4977 in blood leukocytes are associated with increased risk of melanoma and that association is affected by both pigmentation and personal history of sun exposure.<\/jats:p>","DOI":"10.1111\/pcmr.12474","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T11:54:40Z","timestamp":1458302080000},"page":"372-378","source":"Crossref","is-referenced-by-count":8,"title":["Mitochondrial DNA 4977\u2010base pair common deletion in blood leukocytes and melanoma risk"],"prefix":"10.1111","volume":"29","author":[{"given":"Jie","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Epidemiology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Huff","sequence":"additional","affiliation":[{"name":"Department of Epidemiology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenying","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-2187-8-12"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0921-8734(92)90020-P"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.suppl_2.207"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-261982"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.02.035"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22452"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600773"},{"key":"e_1_2_6_9_1","first-page":"1704","article-title":"Detection of the ageing\u2010associated 5\u2010Kb common deletion of mitochondrial DNA in blood and bone marrow of hematologically normal adults. Absence of the deletion in clonal bone marrow disorders","volume":"9","author":"Gattermann N.","year":"1995","journal-title":"Leukemia"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/860479"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2009.04.018"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.3028"},{"issue":"2","key":"e_1_2_6_13_1","first-page":"S2\u201038\u201043","article-title":"Mitochondrial DNA deletions in skin from melanoma patients","volume":"18","author":"Hubbard K.","year":"2008","journal-title":"Ethn. Dis."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-002-0745-7"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2005.10.001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/908797"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2013.3035"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-158485"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1634"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2013.0400337"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.07.105"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12298"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-2869-1_2"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2010.07.010"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11624"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-7249(03)00033-3"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2007.00323.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131649"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0921-8734(92)90019-L"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/153537020222700901"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e3282f1d312"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2007.07.003"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2010.01.005"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-007-0740-2"}],"container-title":["Pigment Cell &amp; Melanoma Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpcmr.12474","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.12474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:49:05Z","timestamp":1695491345000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcmr.12474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,21]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/pcmr.12474"],"URL":"https:\/\/doi.org\/10.1111\/pcmr.12474","archive":["Portico"],"relation":{},"ISSN":["1755-1471","1755-148X"],"issn-type":[{"value":"1755-1471","type":"print"},{"value":"1755-148X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,21]]}}}