{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:19:06Z","timestamp":1777933146565,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T00:00:00Z","timestamp":1466380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CSIR project \u2018TOUCH\u2019","award":["BSC0302"],"award-info":[{"award-number":["BSC0302"]}]},{"name":"INSPIRE Faculty Fellows","award":["IFA12-LSBM-038"],"award-info":[{"award-number":["IFA12-LSBM-038"]}]},{"name":"INSPIRE Faculty Fellows","award":["IFA12-LSBM-035"],"award-info":[{"award-number":["IFA12-LSBM-035"]}]},{"name":"CSIR project \u2018VISION\u2019","award":["BSC0403"],"award-info":[{"award-number":["BSC0403"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Vitiligo is a multifactorial acquired depigmenting disorder. Recent insights into the molecular mechanisms driving the gradual destruction of melanocytes in vitiligo will likely lead to the discovery of novel therapies, which need to be evaluated in animal models that closely recapitulate the pathogenesis of human vitiligo. In humans, vitiligo is characterized by a spontaneous loss of functional melanocytes from the epidermis, but most animal models of vitiligo are either inducible or genetically programmed. Here, we report that acquired depigmentation in water buffalo recapitulates molecular, histological, immunohistochemical, and ultrastructural changes observed in human vitiligo and hence could be used as a model to study vitiligo pathogenesis and facilitate the discovery and evaluation of therapeutic interventions for vitiligo.<\/jats:p>","DOI":"10.1111\/pcmr.12485","type":"journal-article","created":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T21:35:22Z","timestamp":1461965722000},"page":"465-469","source":"Crossref","is-referenced-by-count":11,"title":["Water Buffalo (Bubalus bubalis) as a spontaneous animal model of Vitiligo"],"prefix":"10.1111","volume":"29","author":[{"given":"Vijay Pal","family":"Singh","sequence":"first","affiliation":[{"name":"Systems Biology Group CSIR\u2010Institute of Genomics and Integrative Biology New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajender K.","family":"Motiani","sequence":"additional","affiliation":[{"name":"Systems Biology Group CSIR\u2010Institute of Genomics and Integrative Biology New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Archana","family":"Singh","sequence":"additional","affiliation":[{"name":"Systems Biology Group CSIR\u2010Institute of Genomics and Integrative Biology New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garima","family":"Malik","sequence":"additional","affiliation":[{"name":"Systems Biology Group CSIR\u2010Institute of Genomics and Integrative Biology New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rangoli","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Systems Biology Group CSIR\u2010Institute of Genomics and Integrative Biology New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3888-2577","authenticated-orcid":false,"given":"Kunal","family":"Pratap","sequence":"additional","affiliation":[{"name":"Systems Biology Group CSIR\u2010Institute of Genomics and Integrative Biology New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohan R.","family":"Wani","sequence":"additional","affiliation":[{"name":"National Centre for Cell Science Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh B.","family":"Gokhale","sequence":"additional","affiliation":[{"name":"BAIF Development Research Foundation Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek T.","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Systems Biology Group CSIR\u2010Institute of Genomics and Integrative Biology New Delhi India"},{"name":"Academy of Scientific and Innovative Research New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh S.","family":"Gokhale","sequence":"additional","affiliation":[{"name":"Systems Biology Group CSIR\u2010Institute of Genomics and Integrative Biology New Delhi India"},{"name":"Academy of Scientific and Innovative Research New Delhi India"},{"name":"National Institute of Immunology New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.11.061"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(92)90188-T"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.1993.tb00577.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsi.2014.09.008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2340\/0001555576429432","article-title":"Photoprotection in vitiligo and normal skin. 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