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Patients develop benign tumours from several types of cells including neural crest\u2010derived cells. <jats:italic><jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1<\/jats:italic> somatic mutations also occur in 15% of sporadic melanoma, a cancer originating from melanocytes. Evidence now suggests the involvement of <jats:italic><jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1<\/jats:italic> mutations in melanoma resistance to targeted therapies. Although <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 is ubiquitously expressed, genetic links between <jats:italic><jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1<\/jats:italic> and genes involved in melanocyte biology have been described, implying the lineage\u2010specific mechanisms. In this review, we summarize and discuss the latest advances related to the roles of <jats:italic><jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1<\/jats:italic> in melanocyte biology and in cutaneous melanoma.<\/jats:p>","DOI":"10.1111\/pcmr.12488","type":"journal-article","created":{"date-parts":[[2016,5,7]],"date-time":"2016-05-07T15:29:43Z","timestamp":1462634983000},"page":"417-425","source":"Crossref","is-referenced-by-count":15,"title":["Multiple roles of NF1 in the melanocyte lineage"],"prefix":"10.1111","volume":"29","author":[{"given":"Lionel","family":"Larrib\u00e8re","sequence":"first","affiliation":[{"name":"Skin Cancer Unit German Cancer Research Center (DKFZ) Heidelberg Germany"},{"name":"Department of Dermatology, Venereology and Allergology University Medical Center Mannheim Ruprecht\u2010Karl University of Heidelberg Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Utikal","sequence":"additional","affiliation":[{"name":"Skin Cancer Unit German Cancer Research Center (DKFZ) Heidelberg Germany"},{"name":"Department of Dermatology, Venereology and Allergology University Medical Center Mannheim Ruprecht\u2010Karl University of Heidelberg Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.07.049"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.044"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1501032112"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.13.1.487"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.03.035"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90018-3"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10166"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80415-3"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01153-08"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23403"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70033-6"},{"key":"e_1_2_11_13_1","first-page":"1473","article-title":"Next\u2010generation sequencing identifies rare variants associated with Noonan syndrome","volume":"111","author":"Chen P.\u2010C.","year":"2014","journal-title":"Proc. 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