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Here, we find that rhododendrol treatment leads to a reduction in the levels of cellular glutathione but also induces a cellular antioxidant response that eventually increases glutathione levels. We further find that rhododendrol toxicity is enhanced when glutathione levels are experimentally reduced and alleviated when glutathione levels are increased. Hence, it appears that the size of the preexisting glutathione pool along with the capacity to supply glutathione via the antioxidant response determines whether melanocytes survive or die after rhododendrol exposure. It is conceivable, therefore, that rhododendrol\u2010induced leukoderma depends on the capacity to maintain appropriate glutathione levels and that enhancement of glutathione levels may preserve a patient's melanocytes and potentially help in repigmentation.<\/jats:p>","DOI":"10.1111\/pcmr.12494","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T20:21:44Z","timestamp":1464207704000},"page":"541-549","source":"Crossref","is-referenced-by-count":23,"title":["Glutathione maintenance is crucial for survival of melanocytes after exposure to rhododendrol"],"prefix":"10.1111","volume":"29","author":[{"given":"Masatoshi","family":"Kondo","sequence":"first","affiliation":[{"name":"Biological Science Research Kao Corporation Odawara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keigo","family":"Kawabata","sequence":"additional","affiliation":[{"name":"Biological Science Research Kao Corporation Odawara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohji","family":"Sato","sequence":"additional","affiliation":[{"name":"Analytical Science Research Kao Corporation Odawara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayuri","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Biological Science Research Kao Corporation Odawara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Hachiya","sequence":"additional","affiliation":[{"name":"Biological Science Research Kao Corporation Odawara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Biological Science Research Kao Corporation Odawara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Inoue","sequence":"additional","affiliation":[{"name":"Kanebo Cosmetics Inc. 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